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Cross\u2010sectional data on 766 girls, aged 15 years and under, with genetically confirmed Rett syndrome was obtained from the Australian Rett Syndrome Database (ARSD) (n\u2009=\u2009244) and the International Rett Syndrome Phenotype Database (InterRett) (n\u2009=\u2009522). Relationships between\n                      <jats:italic>MECP2<\/jats:italic>\n                      mutation type and age of regression in speech\u2010language abilities, and the level of speech\u2010language abilities before and after this regression were investigated. The females had a median age of 4.95 years in the ARSD and 5.25 years in InterRett. The majority (89%, 685\/766) acquired speech\u2010language abilities in the form of babble or words at some point in time. Of those who acquired babble or words, 85% (581\/685) experienced a regression in these abilities. Those with a p.Arg133Cys mutation were the most likely to use one or more words, prior to (RRR\u2009=\u20093.45; 95% CI 1.15\u201310.41) and after (RRR\u2009=\u20095.99; 95% CI 2.00\u201317.92), speech\u2010language regression. Girls with Rett syndrome vary in their use of speech and language, and in their experience of speech\u2010language regression and these variations are partly explained by genotype. \u00a9 2014 Wiley Periodicals, Inc.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ajmg.a.36871","type":"journal-article","created":{"date-parts":[[2014,11,26]],"date-time":"2014-11-26T12:50:10Z","timestamp":1417006210000},"page":"354-362","source":"Crossref","is-referenced-by-count":32,"title":["Aspects of speech\u2010language abilities are influenced by\n                    <i>MECP2<\/i>\n                    mutation type in girls with Rett syndrome"],"prefix":"10.1002","volume":"167","author":[{"given":"Anna","family":"Urbanowicz","sequence":"first","affiliation":[{"name":"Telethon Kids Institute The University of Western Australia Australia"},{"name":"School of Exercise and Health Sciences Edith Cowan University Perth WA 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