{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T16:11:44Z","timestamp":1790784704199,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,1,13]],"date-time":"2015-01-13T00:00:00Z","timestamp":1421107200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"NIH","award":["DE021034"],"award-info":[{"award-number":["DE021034"]}]},{"name":"NSF","award":["DGE0742475"],"award-info":[{"award-number":["DGE0742475"]}]},{"name":"IUPUI Undergraduate Research Opportunity Grants"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J of Med Genetics Pt A"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:sec><jats:label\/><jats:p>Children with Down syndrome (DS) experience congenital and functional medical issues that predispose them to obstructive sleep apnea (OSA). Research utilizing stringent age criteria among samples of infants with DS and OSA is limited. This study examines clinical correlates of OSA among infants with DS. A retrospective chart review was conducted of infants \u22646 months of age referred to a DS clinic at a tertiary children's hospital over five\u2010years (n\u2009=\u2009177). Chi\u2010square tests and binary logistic regression models were utilized to analyze the data. Fifty\u2010nine infants underwent polysomnography, based on clinical concerns. Of these, 95% (56\/59) had studies consistent with OSA. Among infants with OSA, 71% were identified as having severe OSA (40\/56). The minimum overall prevalence of OSA among the larger group of infants was 31% (56\/177). Significant relationships were found between OSA and dysphagia, congenital heart disease (CHD), prematurity, gastroesophageal reflux disease (GERD), and other functional and anatomic gastrointestinal (GI) conditions. Results indicate that odds of OSA in this group are higher among infants with GI conditions in comparison to those without. Co\u2010occurring dysphagia and CHD predicted the occurrence of OSA in 36% of cases with an overall predictive accuracy rate of 71%. Obstructive sleep apnea is relatively common in young infants with DS and often severe. Medical factors including GI conditions, dysphagia and CHD may help to identify infants who are at greater risk and may warrant evaluation. Further studies are needed to assess the impact of OSA in infants with DS. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ajmg.a.36903","type":"journal-article","created":{"date-parts":[[2015,1,13]],"date-time":"2015-01-13T13:13:29Z","timestamp":1421154809000},"page":"324-330","source":"Crossref","is-referenced-by-count":72,"title":["Obstructive sleep apnea in young infants with Down Syndrome evaluated in a Down Syndrome specialty clinic"],"prefix":"10.1002","volume":"167","author":[{"given":"Alida","family":"Goffinski","sequence":"first","affiliation":[{"name":"Leadership Education in Neurodevelopmental Disorders Program Riley Hospital for Children Indianapolis Indiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria A.","family":"Stanley","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Wisconsin School of Medicine and Public Health Madison Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Shepherd","sequence":"additional","affiliation":[{"name":"Department of Biology Indiana University\u2010Purdue University Indianapolis Indianapolis Indiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nichole","family":"Duvall","sequence":"additional","affiliation":[{"name":"Department of Biology Indiana University\u2010Purdue University Indianapolis Indianapolis Indiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra B.","family":"Jenkinson","sequence":"additional","affiliation":[{"name":"Department of Biology Indiana University\u2010Purdue University Indianapolis Indianapolis Indiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlene","family":"Davis","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Indiana University School of Medicine Indianapolis Indiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marilyn J.","family":"Bull","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Indiana University School of Medicine Indianapolis Indiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randall J.","family":"Roper","sequence":"additional","affiliation":[{"name":"Department of Biology Indiana University\u2010Purdue University Indianapolis Indianapolis Indiana"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,1,13]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/34.3.379"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2004-0227"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsmc.2009.04.007"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/dmcn.12376"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2011-1605"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1513\/pats.200708-138MG"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2008.146845"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2011.10.003"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.20393"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/26.8.1006"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.157.7.655"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1754.1995.tb00779.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/0009922809332584"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/00063198-199711000-00013"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2006.05.016"},{"key":"e_1_2_6_17_1","unstructured":"IberC. editor.2007. 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