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His tumor was unresectable at diagnosis and he received neoadjuvant chemotherapy with cisplatin, 5\u2010fluorouracil and vincristine. He developed metabolic acidosis and hyperglycemia during chemotherapy. In addition, he developed anemia, thrombocytopenia and febrile neutropenia. He underwent a combined liver\u2010kidney transplant for local control of his tumor and to treat MMA. He remains in remission more than five years after his transplant. In addition, his transplant has cured his MMA and he is able to tolerate a regular diet without developing metabolic crises. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ajmg.a.36925","type":"journal-article","created":{"date-parts":[[2015,2,18]],"date-time":"2015-02-18T06:39:36Z","timestamp":1424241576000},"page":"635-638","source":"Crossref","is-referenced-by-count":20,"title":["Hepatoblastoma in a patient with methylmalonic aciduria"],"prefix":"10.1002","volume":"167","author":[{"given":"Randall","family":"Chan","sequence":"first","affiliation":[{"name":"Division of Pediatric Hematology\/Oncology Los Angeles County+University of Southern California Medical Center Los Angeles California"},{"name":"Department of Pediatrics, Keck School of Medicine University of Southern California Los Angeles California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leo","family":"Mascarenhas","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Keck School of Medicine University of Southern California Los Angeles California"},{"name":"Division of Hematology,Oncology and BMT Children's Hospital Los Angeles Los Angeles California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard G","family":"Boles","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Keck School of Medicine University of Southern California Los Angeles California"},{"name":"Division of Medical Genetics Children's Hospital Los Angeles Los Angeles California"},{"name":"Courtagen Life Sciences Woburn Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nanda","family":"Kerkar","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Keck School of Medicine University of Southern California Los Angeles California"},{"name":"Pediatric Liver and Intestinal Transplant Program Division of Gastroenterology and Nutrition Children's Hospital Los Angeles Los Angeles California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuri","family":"Genyk","sequence":"additional","affiliation":[{"name":"Division of General Pediatric Surgery Children's Hospital Los Angeles Los Angeles California"},{"name":"Department of Surgery, Keck School of Medicine University of Southern California Los Angeles California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajkumar","family":"Venkatramani","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Keck School of Medicine University of Southern California Los Angeles California"},{"name":"Division of Hematology,Oncology and BMT Children's Hospital Los Angeles Los Angeles California"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,2,18]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003072-199312000-00004"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3046.2006.00511.x"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00711749"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2013.05.001"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1992.tb38659.x"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2008.06.007"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2003.50375"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10545-005-7056-1"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(98)70008-3"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.30090"},{"key":"e_1_2_4_12_1","first-page":"477","article-title":"Increased prevalence of malignancy in adult mitochondrial disorders","volume":"6","author":"Finsterer J","year":"2013","journal-title":"J. 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