{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T13:02:55Z","timestamp":1792069375706,"version":"4.4.0"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,2,13]],"date-time":"2015-02-13T00:00:00Z","timestamp":1423785600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J of Med Genetics Pt A"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:sec><jats:label\/><jats:p>Movement abnormalities are frequently reported in children with 22q11.2 deletion syndrome (22q11.2DS), but knowledge in this area is scarce in the increasing adult population. We report on five individuals illustrative of movement disorders and other motor abnormalities in adults with 22q11.2DS. In addition to an increased susceptibility to neuropsychiatric disorders, seizures, and early\u2010onset Parkinson disease, the underlying brain dysfunction associated with 22q11.2DS may give rise to an increased vulnerability to multiple movement abnormalities, including those influenced by medications. Movement abnormalities may also be secondary to treatable endocrine diseases and congenital musculoskeletal abnormalities. We propose that movement abnormalities may be common in adults with 22q11.2DS and discuss the implications and challenges important to clinical practice. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ajmg.a.36928","type":"journal-article","created":{"date-parts":[[2015,2,13]],"date-time":"2015-02-13T13:31:37Z","timestamp":1423834297000},"page":"639-645","source":"Crossref","is-referenced-by-count":53,"title":["Movement disorders and other motor abnormalities in adults with 22q11.2 deletion syndrome"],"prefix":"10.1002","volume":"167","author":[{"given":"Erik","family":"Boot","sequence":"first","affiliation":[{"name":"The Dalglish Family Hearts and Minds Clinic for Adults with 22q11.2 Deletion Syndrome Toronto Ontario Canada"},{"name":"Department of Nuclear Medicine Academic Medical Centre Amsterdam The Netherlands"},{"name":"Department of Psychiatry University Health Network Toronto Ontario Canada"},{"name":"Department of Psychiatry University of Toronto Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy J","family":"Butcher","sequence":"additional","affiliation":[{"name":"Clinical Genetics Research Program Centre for Addiction and Mental Health Toronto Ontario Canada"},{"name":"Institute of Medical Science University of Toronto Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Th\u00e9r\u00e8se AMJ","family":"van Amelsvoort","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychology School of Mental Health and Neuroscience Maastricht University Medical Centre Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony E","family":"Lang","sequence":"additional","affiliation":[{"name":"Institute of Medical Science University of Toronto Toronto Ontario Canada"},{"name":"Department of Medicine Division of Neurology University of Toronto Toronto Ontario Canada"},{"name":"Department of Medicine Tanz Centre for Research in Neurodegenerative Diseases University of Toronto Toronto Ontario Canada"},{"name":"Toronto Western Hospital Research Institute University Health Network Toronto Ontario Canada"},{"name":"Morton and Gloria Shulman Movement Disorder Centre and the Edmond J. Safra Program in Parkinson's Disease Toronto Western Hospital University Health Network and University of Toronto Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Connie","family":"Marras","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Neurology University of Toronto Toronto Ontario Canada"},{"name":"Morton and Gloria Shulman Movement Disorder Centre and the Edmond J. Safra Program in Parkinson's Disease Toronto Western Hospital University Health Network and University of Toronto Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margarita","family":"Pondal","sequence":"additional","affiliation":[{"name":"Morton and Gloria Shulman Movement Disorder Centre and the Edmond J. Safra Program in Parkinson's Disease Toronto Western Hospital University Health Network and University of Toronto Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle M","family":"Andrade","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Neurology University of Toronto Toronto Ontario Canada"},{"name":"Epilepsy Genetics Program Toronto Western Hospital University Health Network and University of Toronto Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wai Lun Alan","family":"Fung","sequence":"additional","affiliation":[{"name":"The Dalglish Family Hearts and Minds Clinic for Adults with 22q11.2 Deletion Syndrome Toronto Ontario Canada"},{"name":"Department of Psychiatry University Health Network Toronto Ontario Canada"},{"name":"Department of Psychiatry University of Toronto Toronto Ontario Canada"},{"name":"Clinical Genetics Research Program Centre for Addiction and Mental Health Toronto Ontario Canada"},{"name":"Toronto General Research Institute University Health Network Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne S","family":"Bassett","sequence":"additional","affiliation":[{"name":"The Dalglish Family Hearts and Minds Clinic for Adults with 22q11.2 Deletion Syndrome Toronto Ontario Canada"},{"name":"Department of Psychiatry University Health Network Toronto Ontario Canada"},{"name":"Department of Psychiatry University of Toronto Toronto Ontario Canada"},{"name":"Clinical Genetics Research Program Centre for Addiction and Mental Health Toronto Ontario Canada"},{"name":"Institute of Medical Science University of Toronto Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,2,13]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2011.02.039"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.4103\/0253-7176.122249"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.33665"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2013.3646"},{"key":"e_1_2_4_6_1","article-title":"Response to clozapine in a clinically identifiable subtype of schizophrenia: 22q11 .2 deletions mediate side effect risk and dosage","author":"Butcher NJ","journal-title":"Br J Psychiatry"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ddrr.6"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.20112"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/cen.12466"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2006.04.007"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmedgenet-2011-100440"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.111.097139"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jir.12117"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2010.09101463"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/hup.918"},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.1597\/12-318"},{"key":"e_1_2_4_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ridd.2012.03.023"},{"key":"e_1_2_4_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.30133"},{"key":"e_1_2_4_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00247-008-0903-0"},{"key":"e_1_2_4_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbn146"},{"key":"e_1_2_4_21_1","doi-asserted-by":"publisher","DOI":"10.4065\/73.10.956"},{"key":"e_1_2_4_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(10)70112-5"},{"key":"e_1_2_4_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(13)70011-5"},{"key":"e_1_2_4_24_1","doi-asserted-by":"publisher","DOI":"10.1177\/0009922813506606"},{"key":"e_1_2_4_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2010.04.073"},{"key":"e_1_2_4_26_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2013.13070864"},{"key":"e_1_2_4_27_1","doi-asserted-by":"publisher","DOI":"10.1021\/cn400189s"},{"key":"e_1_2_4_28_1","first-page":"79","article-title":"The behavioural phenotype in velo\u2010cardio\u2010facial syndrome (VCFS): From infancy to adolescence","volume":"10","author":"Swillen A","year":"1999","journal-title":"Genet Couns"},{"key":"e_1_2_4_29_1","doi-asserted-by":"publisher","DOI":"10.1080\/09297040902740678"},{"key":"e_1_2_4_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/00125817-200101000-00005"}],"container-title":["American Journal of Medical Genetics Part A"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajmg.a.36928","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajmg.a.36928","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajmg.a.36928","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T18:49:25Z","timestamp":1696618165000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajmg.a.36928"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2,13]]},"references-count":29,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,3]]}},"alternative-id":["10.1002\/ajmg.a.36928"],"URL":"https:\/\/doi.org\/10.1002\/ajmg.a.36928","archive":["Portico"],"relation":{},"ISSN":["1552-4825","1552-4833"],"issn-type":[{"value":"1552-4825","type":"print"},{"value":"1552-4833","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,2,13]]}}}