{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T17:36:49Z","timestamp":1791394609641,"version":"4.3.3"},"reference-count":40,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,2,25]],"date-time":"2015-02-25T00:00:00Z","timestamp":1424822400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Dutch Prader-Willi Fund"},{"name":"Fund NutsOhra"},{"name":"Dutch Growth Research Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J of Med Genetics Pt A"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:sec><jats:label\/><jats:p>Psychiatric disorders such as psychosis are highly prevalent in adults with Prader\u2013Willi syndrome (PWS). However, knowledge about the presence and progression of psychiatric disorders in children with PWS is very limited. Sixty\u2010one children with PWS aged 7\u201317 years were tested using the Diagnostic Interview Schedule for Children (DISC) and Compulsive Behaviour Checklist (CBC), and 38\/61 were retested after 2 years. Prevalence of psychiatric disorders and the association with age, gender, genetic subtype, and total IQ were assessed. In addition, occurrence and characteristics of compulsions were determined.<\/jats:p><jats:p>Prior to the study, two boys were known with psychotic symptoms and treated with antipsychotics. At baseline, none scored positive for psychotic disorder. During the follow\u2010up, only one boy with known psychotic symptoms required a dose adjustment of his antipsychotic medication. After 2 years, none of the children had a psychotic disorder according to the DISC. Oppositional defiant disorder (ODD) was the most common diagnosis and present in 20% of children with PWS, and this was not associated with age (\u03b2\u2009=\u2009\u22120.081, <jats:italic>P<\/jats:italic>\u2009=\u20090.546), gender (\u03b2\u2009=\u20090.013, <jats:italic>P<\/jats:italic>\u2009=\u20090.923), genetic subtype (\u03b2\u2009=\u2009\u22120.073, <jats:italic>P<\/jats:italic>\u2009=\u20090.584), or total IQ (\u03b2\u2009=\u2009\u22120.150, <jats:italic>P<\/jats:italic>\u2009=\u20090.267). The most common compulsions were hoarding and fixed hygiene sequences.<\/jats:p><jats:p>In our large group of 61 children with PWS, the majority had no psychotic disorder and no progression was found during 2\u2010year follow\u2010up. ODD was present in 20% of children. No changes in the prevalence of psychiatric disorders were found during the 2\u2010year follow\u2010up study and genetic subtype was not related to psychosis, depression, or ODD. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ajmg.a.36998","type":"journal-article","created":{"date-parts":[[2015,2,25]],"date-time":"2015-02-25T11:42:46Z","timestamp":1424864566000},"page":"983-991","source":"Crossref","is-referenced-by-count":29,"title":["Psychiatric disorders in children with Prader\u2013Willi syndrome\u2014Results of a 2\u2010year longitudinal study"],"prefix":"10.1002","volume":"167","author":[{"given":"S.T.","family":"Lo","sequence":"first","affiliation":[{"name":"Dutch Growth Research Foundation Rotterdam The Netherlands"},{"name":"Department of Pediatrics Erasmus University Medical Center\/Sophia Children's Hospital Subdivision of Endocrinology Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.J.L.","family":"Collin","sequence":"additional","affiliation":[{"name":"de Koraalgroep Sittard The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.C.S.","family":"Hokken\u2010Koelega","sequence":"additional","affiliation":[{"name":"Dutch Growth Research Foundation Rotterdam The Netherlands"},{"name":"Department of Pediatrics Erasmus University Medical Center\/Sophia Children's Hospital Subdivision of Endocrinology Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,2,25]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.141.10.3879"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004583-199906000-00025"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.1991.tb14950.x"},{"key":"e_1_2_7_5_1","volume-title":"Diagnostic and statistical manual of mental disorders","year":"1994"},{"key":"e_1_2_7_6_1","volume-title":"DSM\u2010IV\u2010TR","year":"2000"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-2012"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)07340-3"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19970211)68:4<433::AID-AJMG12>3.0.CO;2-T"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.163.5.680"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.180.4.358"},{"key":"e_1_2_7_12_1","first-page":"325","article-title":"Psychose bij kinderen met het Prader\u2013Willi syndrome","volume":"47","author":"Collin PJL","year":"2005","journal-title":"Tijdschr Psychiatr"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.106.022483"},{"key":"e_1_2_7_14_1","first-page":"77","volume-title":"Five\u2010year development of psychopathology in young people with intellectual disabilities","author":"de Ruiter K","year":"2013"},{"key":"e_1_2_7_15_1","unstructured":"DimitropoulosA.2003. 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