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The data suggest a distinctive benefit to treating an NF1 patient with an inhibitor of mast cell degranulation <jats:italic>before<\/jats:italic> cutaneous neurofibromas are clinically apparent: the neurofibromas appear to be arrested at a very early stage of development. The patient's skin was especially remarkable for both the paucity of cutaneous neurofibromas and the distinctive monotonous uniformity of those present, which were small and flat or barely sessile. While the data do not, of themselves, prove that ketotifen treatment commencing in childhood preempts neurofibroma maturation, in the context of earlier publications, they certainly warrant further investigation. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ajmg.a.37045","type":"journal-article","created":{"date-parts":[[2015,5,14]],"date-time":"2015-05-14T06:31:24Z","timestamp":1431585084000},"page":"1570-1577","source":"Crossref","is-referenced-by-count":35,"title":["Ketotifen suppression of NF1 neurofibroma growth over 30 years"],"prefix":"10.1002","volume":"167","author":[{"given":"Vincent M.","family":"Riccardi","sequence":"first","affiliation":[{"name":"The Neurofibromatosis Institute La Crescenta 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