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We postulate a role for the histone deacetylase <jats:italic>HDAC1<\/jats:italic> in the facial phenotype and suggest that deletion of <jats:italic>KPNA6<\/jats:italic> may prevent transmission of the 1p35.2 deletion from affected girls to any offspring through impaired zygotic genome activation. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ajmg.a.37114","type":"journal-article","created":{"date-parts":[[2015,4,22]],"date-time":"2015-04-22T03:49:18Z","timestamp":1429674558000},"page":"1916-1920","source":"Crossref","is-referenced-by-count":4,"title":["Microdeletion 1p35.2: A recognizable facial phenotype with developmental delay"],"prefix":"10.1002","volume":"167","author":[{"given":"Brian T.","family":"Wilson","sequence":"first","affiliation":[{"name":"Institute of Genetic Medicine Newcastle University International Centre for Life Newcastle upon Tyne UK"},{"name":"Northern Genetics Service Newcastle upon Tyne Hospitals NHS Foundation Trust International Centre for Life Newcastle upon Tyne UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Murwan","family":"Omer","sequence":"additional","affiliation":[{"name":"National Centre for Medical Genetics Our Lady's Children's Hospital Crumlin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen W.","family":"Hellens","sequence":"additional","affiliation":[{"name":"Northern Genetics Service Newcastle upon Tyne Hospitals NHS Foundation Trust International Centre for Life Newcastle upon Tyne UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon A.","family":"Zwolinski","sequence":"additional","affiliation":[{"name":"Northern Genetics Service Newcastle upon Tyne Hospitals NHS Foundation Trust International Centre for Life Newcastle upon Tyne UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura M.","family":"Yates","sequence":"additional","affiliation":[{"name":"Institute of Genetic Medicine Newcastle University International Centre for Life Newcastle upon Tyne UK"},{"name":"Northern Genetics Service Newcastle upon Tyne Hospitals NHS Foundation Trust International Centre for Life Newcastle upon Tyne UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sally Ann","family":"Lynch","sequence":"additional","affiliation":[{"name":"National Centre for Medical Genetics Our Lady's Children's Hospital Crumlin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,4,21]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.775"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.00713-12"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.215988"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkr765"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2012.02.007"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.11.028"},{"key":"e_1_2_5_8_1","first-page":"27","article-title":"Paris Autism Research International Sibpair (PARIS) Study. 2003. 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