{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T22:00:01Z","timestamp":1773180001142,"version":"3.50.1"},"reference-count":44,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2015,5,1]],"date-time":"2015-05-01T00:00:00Z","timestamp":1430438400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Centers for Disease Control and Prevention to the Centers for Birth Defects Research and Prevention","award":["PA 96043"],"award-info":[{"award-number":["PA 96043"]}]},{"name":"Centers for Disease Control and Prevention to the Centers for Birth Defects Research and Prevention","award":["PA 02081"],"award-info":[{"award-number":["PA 02081"]}]},{"name":"Centers for Disease Control and Prevention to the Centers for Birth Defects Research and Prevention","award":["PA 09001"],"award-info":[{"award-number":["PA 09001"]}]},{"name":"Centers for Disease Control and Prevention to the Centers for Birth Defects Research and Prevention","award":["FOA DD000490"],"award-info":[{"award-number":["FOA DD000490"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J of Med Genetics Pt A"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:sec><jats:label\/><jats:p>Dandy\u2013Walker malformation (DWM) is the most common congenital malformation of the cerebellum, but its causes are largely unknown. An increasing number of genes associated with congenital cerebellar malformations have been identified; however, few studies have examined the potential role of non\u2010genetic, potentially modifiable risk factors. From the National Birth Defects Prevention Study, we examined maternal, paternal, and infant characteristics and maternal conditions and periconceptional exposures (from 1 month before to 3 months after conception) among infants with DWM (n\u2009=\u2009160) and unaffected controls (n\u2009=\u200910,200), delivered between 1997 and 2009. Odds ratios, crude (cOR) and adjusted (aOR) were computed using logistic regression. Maternal factors associated with DWM included non\u2010Hispanic black race\/ethnicity (aOR\u2009=\u20092.0, 95%CI: 1.3\u20133.2). Among maternal conditions, a history of infertility increased the risk for DWM (all: aOR\u2009=\u20092.4, 95%CI: 1.3\u20134.6; multiple: aOR\u2009=\u20093.9, 95%CI: 1.7\u20138.9). The lack of association with many maternal exposures supports the hypothesis of a major contribution of genetic factors to the risk for DWM; however, the observed associations with maternal non\u2010Hispanic black race\/ethnicity and maternal history of infertility indicate that further research into factors underlying these characteristics may uncover potentially modifiable risk factors, acting alone or as a component of gene\u2013environment interactions. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ajmg.a.37124","type":"journal-article","created":{"date-parts":[[2015,5,2]],"date-time":"2015-05-02T03:06:55Z","timestamp":1430536015000},"page":"2009-2016","source":"Crossref","is-referenced-by-count":15,"title":["Risk factors for Dandy\u2013Walker malformation: A population\u2010based assessment"],"prefix":"10.1002","volume":"167","author":[{"given":"Matthew R.","family":"Reeder","sequence":"first","affiliation":[{"name":"Division of Medical Genetics, Department of Pediatrics University of Utah School of Medicine Salt Lake City Utah"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorenzo D.","family":"Botto","sequence":"additional","affiliation":[{"name":"Division of Medical Genetics, Department of Pediatrics University of Utah School of Medicine Salt Lake City Utah"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kim M.","family":"Keppler\u2010Noreuil","sequence":"additional","affiliation":[{"name":"National Human Genome Research Institute National Institutes of Health Bethesda Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John C.","family":"Carey","sequence":"additional","affiliation":[{"name":"Division of Medical Genetics, Department of Pediatrics University of Utah School of Medicine Salt Lake City Utah"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janice L. 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