{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T11:31:07Z","timestamp":1790767867489,"version":"4.1.0"},"reference-count":58,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2015,7,14]],"date-time":"2015-07-14T00:00:00Z","timestamp":1436832000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Alberta Health, Edmonton, Alberta, Canada"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J of Med Genetics Pt A"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:sec><jats:label\/><jats:p>The birth prevalence of limb deficiencies in Alberta has been fluctuating. The objectives were to examine patterns and temporal trends of congenital limb deficiencies in Alberta and compare rates with those of other jurisdictions. The Alberta Congenital Anomalies Surveillance System data on live births, stillbirths, and terminations of pregnancy (&lt;20 weeks gestation) occurring between 1980 through 2012 with the ICD\u201010 Royal College of Paediatrics and Child Health Adaptations codes Q71\u2010Q73 (limb reduction defects), Q79.80 (congenital constriction bands), and Q87.24 (sirenomelia syndrome) were reviewed. Cases were classified as having amelia, transverse, longitudinal (preaxial, postaxial, central, or mixed), intercalary, split hand\/split foot, complex, or other type of limb deficiency. Phenotypes were classified as associated, which included cases with a known etiology and cases with at least one other type of anomaly, or isolated. From 1980 through 2012, 795 cases were ascertained from 1,411,652 live births and stillbirths, giving a prevalence of 5.6\/10,000 total births. Mixed longitudinal deficiencies were the most common (22.4%). The upper limbs (63.9%) were affected more often than the lower limbs (25.3%). Isolated limb deficiencies occurred in 43.6% of cases, 28.4% had Mendelian or other known conditions, 21.9% had multiple congenital anomalies, 5.4% had chromosome abnormalities and 0.6% were due to teratogens. The associated group, showed a significant increasing trend (<jats:italic>P<\/jats:italic>\u2009=\u2009 0.023). While the overall limb deficiency rates show very little differences across diverse populations and differing time periods, comparisons of subgroups should be made with caution, because variations in terminology and classification contribute to reported differences. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ajmg.a.37240","type":"journal-article","created":{"date-parts":[[2015,7,14]],"date-time":"2015-07-14T15:46:58Z","timestamp":1436888818000},"page":"2599-2609","source":"Crossref","is-referenced-by-count":47,"title":["Congenital limb deficiencies in Alberta\u2014a review of 33 years (1980\u20132012) from the Alberta Congenital Anomalies Surveillance System (ACASS)"],"prefix":"10.1002","volume":"167","author":[{"given":"Tanya","family":"Bedard","sequence":"first","affiliation":[{"name":"Alberta Congenital Anomalies Surveillance System, Alberta Health and Wellness Alberta Children's Hospital Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert Brian","family":"Lowry","sequence":"additional","affiliation":[{"name":"Alberta Congenital Anomalies Surveillance System, Alberta Health and Wellness Alberta Children's Hospital Calgary Alberta Canada"},{"name":"Departments of Pediatrics and Medical Genetics University of Calgary and Alberta Children's Hospital Calgary Alberta Canada"},{"name":"Alberta Children's Hospital Research Institute Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Sibbald","sequence":"additional","affiliation":[{"name":"Alberta Congenital Anomalies Surveillance System, Alberta Health and Wellness Alberta Children's Hospital Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerhard N.","family":"Kiefer","sequence":"additional","affiliation":[{"name":"Alberta Congenital Anomalies Surveillance System, Alberta Health and Wellness Alberta Children's Hospital Calgary Alberta Canada"},{"name":"Department of Surgery, Alberta Children's Hospital University of Calgary Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Metcalfe","sequence":"additional","affiliation":[{"name":"Alberta Congenital Anomalies Surveillance System, Alberta Health and Wellness Alberta Children's Hospital Calgary Alberta Canada"},{"name":"Alberta Children's Hospital Research Institute Calgary Alberta Canada"},{"name":"Department of Obstetrics\/Gynecology University of Calgary Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,7,14]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"Alberta Health Surveillance and Assessment. 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