{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T14:14:17Z","timestamp":1761920057710},"reference-count":13,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2015,9,3]],"date-time":"2015-09-03T00:00:00Z","timestamp":1441238400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J of Med Genetics Pt A"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:sec><jats:label \/><jats:p>Interstitial deletions on the long arm of chromosome six have been described for several regions including 6q16, 6q22.1, and 6q21q22.1, and with variable phenotypes such as intellectual disability\/developmental delay, growth retardation, major and minor facial anomalies. However, an isolated microdeletion of the sub\u2010band 6q22.33 has not been reported so far and thus, no information about the specific phenotype associated with such a copy number variant is available. Here, we define the clinical picture of an isolated 6q22.33 microdeletion based on the phenotype of six members of one family with loss of approximately 1\u2009Mb in this region. Main clinical features include mild intellectual disability and behavioral abnormalities as well as microcephaly, heart defect, and cleft lip and palate. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ajmg.a.37266","type":"journal-article","created":{"date-parts":[[2015,9,3]],"date-time":"2015-09-03T06:41:31Z","timestamp":1441262491000},"page":"2800-2807","source":"Crossref","is-referenced-by-count":3,"title":["6q22.33 microdeletion in a family with intellectual disability, variable major anomalies, and behavioral abnormalities"],"prefix":"10.1002","volume":"167","author":[{"given":"Luisa","family":"Mackenroth","sequence":"first","affiliation":[{"name":"Institut f \u00fc r Klinische Genetik Medizinische Fakult \u00e4 t Carl Gustav Carus Technische Universit\u00e4t Dresden Dresden Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karl","family":"Hackmann","sequence":"additional","affiliation":[{"name":"Institut f \u00fc r Klinische Genetik Medizinische Fakult \u00e4 t Carl Gustav Carus Technische Universit\u00e4t Dresden Dresden Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anke","family":"Beyer","sequence":"additional","affiliation":[{"name":"Institut f \u00fc r Klinische Genetik Medizinische Fakult \u00e4 t Carl Gustav Carus Technische Universit\u00e4t Dresden Dresden Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jens","family":"Schallner","sequence":"additional","affiliation":[{"name":"Klinik und Poliklinik f\u00fcr Kinder\u2010und Jugendmedizin Universit\u00e4tsklinikum Carl Gustav Carus Dresden Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Novotna","sequence":"additional","affiliation":[{"name":"Klinik und Poliklinik f\u00fcr Kinder\u2010und Jugendmedizin Universit\u00e4tsklinikum Carl Gustav Carus Dresden Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Klink","sequence":"additional","affiliation":[{"name":"Institut f \u00fc r Klinische Genetik Medizinische Fakult \u00e4 t Carl Gustav Carus Technische Universit\u00e4t Dresden Dresden Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evelin","family":"Schr\u00f6ck","sequence":"additional","affiliation":[{"name":"Institut f \u00fc r Klinische Genetik Medizinische Fakult \u00e4 t Carl Gustav Carus Technische Universit\u00e4t Dresden Dresden Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nataliya","family":"Di Donato","sequence":"additional","affiliation":[{"name":"Institut f \u00fc r Klinische Genetik Medizinische Fakult \u00e4 t Carl Gustav Carus Technische Universit\u00e4t Dresden Dresden Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,9,3]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2387"},{"key":"e_1_2_7_3_1","first-page":"111","article-title":"Cleft lip and\/or palate: Review","volume":"63","author":"Farronato G","year":"2014","journal-title":"Minerva Stomatol"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1766"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.28.16712"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.2011.01755.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.31783"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2012.02.007"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2008.09.014"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1586\/14737159.1.2.226"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2008.05.059"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10048-011-0306-5"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2014.75"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2005.03977.x"}],"container-title":["American Journal of Medical Genetics Part A"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajmg.a.37266","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajmg.a.37266","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T20:58:59Z","timestamp":1696625939000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajmg.a.37266"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9,3]]},"references-count":13,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2015,11]]}},"alternative-id":["10.1002\/ajmg.a.37266"],"URL":"https:\/\/doi.org\/10.1002\/ajmg.a.37266","archive":["Portico"],"relation":{},"ISSN":["1552-4825","1552-4833"],"issn-type":[{"value":"1552-4825","type":"print"},{"value":"1552-4833","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,9,3]]}}}