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Deletions with breakpoints within LCR3 and LCR4 have been described to be associated with intellectual disability and dysmorphic features, while the reciprocal duplications are rarely reported. We present an additional case with multiple congenital anomalies that include microcephaly, cardiac defect, and mild intellectual disability, in which a de novo interstitial 8.2\u2010Mb duplication of 10q22.3\u2013q23.3, including <jats:italic>BMPR1A<\/jats:italic> and <jats:italic>NGR3<\/jats:italic>, was identified by Illumina SNP array platform. Our study is consistent with the hypothesis that the <jats:italic>BMPR1A<\/jats:italic> is a plausible candidate gene for congenital heart disease (CHD) and should contribute to the diagnosis and treatment of these genomic diseases. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ajmg.a.37347","type":"journal-article","created":{"date-parts":[[2015,9,18]],"date-time":"2015-09-18T21:43:51Z","timestamp":1442612631000},"page":"3174-3179","source":"Crossref","is-referenced-by-count":11,"title":["Duplication of 10q22.3\u2013q23.3 encompassing <i>BMPR1A<\/i> and <i>NGR3<\/i> associated with congenital heart disease, microcephaly, and mild intellectual disability"],"prefix":"10.1002","volume":"167","author":[{"given":"Mi","family":"Tang","sequence":"first","affiliation":[{"name":"Department of Cardiothoracic Surgery The Second Xiangya Hospital Central South University Changsha Hunan 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