{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T15:48:51Z","timestamp":1764172131712},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,10,13]],"date-time":"2015-10-13T00:00:00Z","timestamp":1444694400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J of Med Genetics Pt A"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:sec><jats:label \/><jats:p>Constitutional 11q interstitial deletion syndrome presents with congenital anomalies including microcephaly with craniostenosis, minor dysmorphic features, vitreoretinopathy, and renal anomalies. This syndrome is occasionally associated with neuroblastoma (NB) as a life\u2010threatening complication, which is important for clinical care. Although the corresponding locus to NB has been predicted to exist in 11q22\u201323 by previous deletion studies related to NB, the causative haploinsufficient genes have not yet been identified. We herein reported for the first time the simultaneous coexistence of adrenal NB and abdominal prevertebral ganglioneuroma in a 6\u2010year\u2010old girl with a constitutional hemizygous 11q14.1\u201323.3 deletion. Of the 11 haploinsufficient genes predicted with an in silico database, we focused on <jats:italic>NCAM1<\/jats:italic> and <jats:italic>CADM1<\/jats:italic> as the genes accountable for NB and ganglioneuroma. The deletion range, especially the 11q22.3 involvement, needs to be determined in 11q deletion cases in order to predict susceptibility to peripheral nerve tumors involving NB and ganglioneuroma. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ajmg.a.37430","type":"journal-article","created":{"date-parts":[[2015,10,14]],"date-time":"2015-10-14T03:37:17Z","timestamp":1444793837000},"page":"492-497","source":"Crossref","is-referenced-by-count":9,"title":["Coexistence of neuroblastoma and ganglioneuroma in a girl with a hemizygous deletion of chromosome 11q14.1\u201323.3"],"prefix":"10.1002","volume":"170","author":[{"given":"Tadashi","family":"Shiohama","sequence":"first","affiliation":[{"name":"Department of Pediatrics Chiba University Graduate School of Medicine Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsunori","family":"Fujii","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Chiba University 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