{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T18:10:35Z","timestamp":1787508635676,"version":"build-2736575974"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,12,21]],"date-time":"2015-12-21T00:00:00Z","timestamp":1450656000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J of Med Genetics Pt A"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      Noonan syndrome (NS) is the second most frequent hereditary syndrome with cardiac involvement. Pulmonary valve stenosis and hypertrophic cardiomyopathy are the most prevalent cardiovascular abnormalities. We report on a 14\u2010year\u2010old girl with NS due to\n                      <jats:italic>SOS1<\/jats:italic>\n                      mutation with pulmonary stenosis and idiopathic coronary ectasia. To the best of our knowledge, this is the first report describing coronary ectasia in a patient with NS secondary to a\n                      <jats:italic>SOS1<\/jats:italic>\n                      mutation. We include a literature review of this rare association. \u00a9 2015 Wiley Periodicals, Inc.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ajmg.a.37505","type":"journal-article","created":{"date-parts":[[2015,12,21]],"date-time":"2015-12-21T00:54:12Z","timestamp":1450659252000},"page":"665-669","source":"Crossref","is-referenced-by-count":19,"title":["Coronary artery ectasia in Noonan syndrome: Report of an individual with\n                    <i>SOS1<\/i>\n                    mutation and literature review"],"prefix":"10.1002","volume":"170","author":[{"given":"Giulio","family":"Calcagni","sequence":"first","affiliation":[{"name":"Department of Pediatric Cardiology and Cardiac Surgery Bambino Ges\u00f9 Children's Hospital IRCCS Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anwar","family":"Baban","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology and Cardiac Surgery Bambino Ges\u00f9 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