{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T22:13:22Z","timestamp":1758924802662},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,12,22]],"date-time":"2015-12-22T00:00:00Z","timestamp":1450742400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J of Med Genetics Pt A"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:sec><jats:label \/><jats:p>Simpson\u2013Golabi\u2013Behmel syndrome (SGBS) is an X\u2010linked condition characterized by pre and post natal overgrowth, facial malformations, and visceral, skeletal, and neurological anomalies. The physical characteristics of SGBS have been well documented; however there is a lack of description regarding the behavioral phenotype. We report the case of a 6\u2010year\u2010old boy, with confirmed deletion of 6\u20138 exons of the glypican\u20103 gene (<jats:italic>GPC3<\/jats:italic>) who presents three distinctive findings: the persistence of the craniopharyngeal canal, an immune\u2010allergic specificity, and a scarcely behavioral phenotype consisting in the association of Austim Spectrum Disorder with accompanying mild intellectual disability and language impairments. He also fulfilled the criteria of Attention Deficit Hyperactivity Disorder and Oppositional Defiant Disorder according to DSM 5 criteria. The specificities of the case are discussed in the light of recent pathophysiological data. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ajmg.a.37518","type":"journal-article","created":{"date-parts":[[2015,12,22]],"date-time":"2015-12-22T13:59:51Z","timestamp":1450792791000},"page":"1035-1039","source":"Crossref","is-referenced-by-count":8,"title":["Distinctive findings in a boy with Simpson\u2013Golabi\u2013Behmel syndrome"],"prefix":"10.1002","volume":"170","author":[{"given":"Soumeyya","family":"Halayem","sequence":"first","affiliation":[{"name":"Department of Child Psychiatry Razi Hospital Manouba Tunisia"},{"name":"Faculty of Medicine of Tunis Tunis Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariem","family":"Hamza","sequence":"additional","affiliation":[{"name":"Faculty of Medicine of Tunis Tunis Tunisia"},{"name":"Department of Child Psychiatry Mongi Slim Hospital La Marsa 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