{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T09:49:31Z","timestamp":1789984171492,"version":"4.0.1"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,1,11]],"date-time":"2016-01-11T00:00:00Z","timestamp":1452470400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J of Med Genetics Pt A"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      Interstitial deletions of the long arm of chromosome 6 are rare. Clinically, these deletions are considered to be part of a unique microdeletion syndrome associated with intellectual disability and speech impairment, typical dysmorphic features, structural anomalies of the brain, microcephaly, and non\u2010specific multiple organ anomalies. The critical region for the interstitial 6q microdeletion phenotype was mapped to 6q24\u20136q25, particularly the 6q25.3 region containing the genes\n                      <jats:italic>ARID1B<\/jats:italic>\n                      and\n                      <jats:italic>ZDHHC14<\/jats:italic>\n                      . It has been hypothesized that haploinsufficiency of these genes impairs normal development of the brain and is responsible for the phenotype. This case report describes a girl presenting with typical features of 6q microdeletion syndrome, including global developmental delay, speech impairment, distinct dysmorphic features, dysgenesis of the corpus callosum, common limb anomalies, and hearing loss. Chromosome analysis by array\u2010CGH revealed a small interstitial 6q deletion spanning approximately 1.1\u2009Mb of DNA and containing only one coding gene,\n                      <jats:italic>ARID1B<\/jats:italic>\n                      . We suggest that\n                      <jats:italic>ARID1B<\/jats:italic>\n                      is the key gene behind 6q microdeletion syndrome, and we discuss its possible role in the phenotypic manifestations. \u00a9 2016 Wiley Periodicals, Inc.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ajmg.a.37553","type":"journal-article","created":{"date-parts":[[2016,1,11]],"date-time":"2016-01-11T23:47:30Z","timestamp":1452556050000},"page":"1257-1261","source":"Crossref","is-referenced-by-count":24,"title":["Interstitial 6q25 microdeletion syndrome:\n                    <i>ARID1B<\/i>\n                    is the key gene"],"prefix":"10.1002","volume":"170","author":[{"given":"Luisa","family":"Ronzoni","sequence":"first","affiliation":[{"name":"Pediatric Highly Intensive Care Unit, Department of Pathophysiology and Transplantation Universit\u00e0 degli Studi di Milano, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Tagliaferri","sequence":"additional","affiliation":[{"name":"Pediatric Highly Intensive Care Unit, Department of Pathophysiology and Transplantation Universit\u00e0 degli Studi di Milano, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arianna","family":"Tucci","sequence":"additional","affiliation":[{"name":"Pediatric Highly Intensive Care Unit, Department of Pathophysiology and Transplantation Universit\u00e0 degli Studi di Milano, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Baccarin","sequence":"additional","affiliation":[{"name":"Medical Genetics Laboratory Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanna","family":"Esposito","sequence":"additional","affiliation":[{"name":"Pediatric Highly Intensive Care Unit, Department of Pathophysiology and Transplantation Universit\u00e0 degli Studi di Milano, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donatella","family":"Milani","sequence":"additional","affiliation":[{"name":"Pediatric Highly Intensive Care Unit, Department of Pathophysiology and Transplantation Universit\u00e0 degli Studi di Milano, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico Milan 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