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Considering the multiple functions of <jats:italic>TPM1<\/jats:italic> gene, we investigated the potential relationship between <jats:italic>TPM1<\/jats:italic> polymorphisms and risk of NSOC in a Chinese Han population. Four tag single nucleotide polymorphisms (tSNPs) of <jats:italic>TPM1<\/jats:italic> (rs11071720, rs3803499, rs12148828, and rs1972041) were selected to conduct a case\u2010control study with 673 NSOC patients and 705 unrelated healthy controls from a Chinese Han population. The SNPs were genotyped by the IPLEX Sequenom MassARRAY platform. SNP rs1972041GA showed a decreased risk of NSOC in heterozygotes (<jats:italic>P\u2009<\/jats:italic>=\u20090.038, OR\u2009=\u20090.77, 95%CI\u2009=\u2009[0.61, 0.99]). Further stratified analysis revealed an enhanced protective effect of the minor allele G at rs197204 on lip with cleft palate (CLP) and cleft lip with or without cleft palate (CL\/P) groups under a codominant or dominant model. No association was observed between the remaining three markers (rs11071720, rs3803499, and rs12148828) and NSOC as well as its subgroups. <jats:italic>TPM1<\/jats:italic> polymorphisms might contribute to the etiology of NSOC, and more emphasis should be placed on <jats:italic>TPM1<\/jats:italic> during craniofacial development. \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ajmg.a.37561","type":"journal-article","created":{"date-parts":[[2016,1,21]],"date-time":"2016-01-21T11:50:56Z","timestamp":1453377056000},"page":"1208-1215","source":"Crossref","is-referenced-by-count":12,"title":["<i>TPM1<\/i> polymorphisms and nonsyndromic orofacial clefts susceptibility in a Chinese Han population"],"prefix":"10.1002","volume":"170","author":[{"given":"Yajing","family":"Qian","sequence":"first","affiliation":[{"name":"Jiangsu Key Laboratory of Oral Diseases Nanjing Medical University Nanjing China"},{"name":"Department of Orthodontics, Affiliated Hospital of 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