{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T17:47:19Z","timestamp":1779126439908,"version":"3.51.4"},"reference-count":62,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,3,29]],"date-time":"2016-03-29T00:00:00Z","timestamp":1459209600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J of Med Genetics Pt A"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:sec><jats:label\/><jats:p>Neurofibromatosis type 1 (NF1) is an autosomal dominant genetic disorder affecting about 1 in 3,500 individuals. Chronic pain is commonly reported among individuals with NF1 and plexiform neurofibroma tumors (PNs). Acceptance and Commitment Therapy (ACT), an empirically supported method for addressing chronic pain, helps individuals re\u2010focus on valued relationships and activities. This pilot study investigated the feasibility and preliminary efficacy of a brief ACT workshop in the NF1 population. Eligible participants included adolescents and young adults (AYA; 12\u201321 years) with NF1 and chronic pain that interfered with daily functioning and their parents. Patients and parents completed baseline measures of pain interference, pain intensity, functional disability, pain acceptance, depression, and anxiety. Then, AYA and parents participated separately in a 2\u2010day small\u2010group ACT workshop. A telephone booster session occurred 1 month post\u2010intervention. Three\u2010month post\u2010treatment measures were completed by mail. Ten adolescents (4 males; M age\u2009=\u200916.9 years) and seven parents provided baseline and 3\u2010month data. Mean satisfaction with the study was moderate to high (3.9 for patients and 4.6 for parents on a 1\u20135 scales). Patients and parents reported significant declines in patients' pain interference at 3 months post\u2010treatment. Patient\u2010reported pain intensity significantly declined from baseline to 3 months. Parents reported marginally greater acceptance of their child's pain. No changes emerged in functional ability or mood. Preliminary findings suggest that a brief ACT group intervention is feasible and may help AYA with NF1 and PNs cope with their chronic pain, although larger randomized studies are needed to confirm treatment efficacy. \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ajmg.a.37623","type":"journal-article","created":{"date-parts":[[2016,3,30]],"date-time":"2016-03-30T01:44:35Z","timestamp":1459302275000},"page":"1462-1470","source":"Crossref","is-referenced-by-count":55,"title":["Acceptance and commitment therapy in youth with neurofibromatosis type 1 (NF1) and chronic pain and their parents: A pilot study of feasibility and preliminary efficacy"],"prefix":"10.1002","volume":"170","author":[{"given":"Staci","family":"Martin","sequence":"first","affiliation":[{"name":"Pediatric Oncology Branch National Cancer Institute, Montgomery County Bethesda Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pamela L.","family":"Wolters","sequence":"additional","affiliation":[{"name":"Pediatric Oncology Branch National Cancer Institute, Montgomery County Bethesda Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary Anne","family":"Toledo\u2010Tamula","sequence":"additional","affiliation":[{"name":"Clinical Research Directorate\/CMRP, Leidos Biomedical Research, Inc. 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