{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T05:13:43Z","timestamp":1790745223646,"version":"4.1.0"},"reference-count":91,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,4,29]],"date-time":"2016-04-29T00:00:00Z","timestamp":1461888000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J of Med Genetics Pt A"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:sec><jats:label\/><jats:p>The Peter the Great Museum of Anthropology and Ethnography (Kunstkamera) in Saint Petersburg is the oldest museum in Russia. It keeps the remains of the anatomical collection of the world\u2010famous 17th century Dutch anatomist Frederik Ruysch. This unique collection was bought and shipped in 1717 by Czar Peter the Great, and presently still comprises more than 900 specimens, a modest number of which concerns specimens with congenital anomalies. We searched for teratological clues in the existing collection and in all his descriptions and correspondence regarding specimens and cases he encountered during his career as <jats:italic>doctor anatomiae<\/jats:italic> and chief instructor of the surgeons and midwives in Amsterdam. A total of 63 teratological specimens and case descriptions were identified in this legacy, including some exceedingly rare anomalies. As it turns out, Ruysch was the first to describe several of the conditions we encountered, including intracranial teratoma, enchondromatosis, and Majewski syndrome. Although his comments pose an interesting view on how congenital anomalies were scientifically perceived in early 18th century Europe, Ruysch mostly refrained from explaining the causes of the conditions he encountered. Instead, he dedicated himself to careful descriptions of his specimens. Almost 300 years after his demise, Ruysch's legacy still impresses and inspires both scientists and lay men. \u00a9 2016 The Authors. <jats:italic>American Journal of Medical Genetics Part A<\/jats:italic> Published by Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ajmg.a.37663","type":"journal-article","created":{"date-parts":[[2016,4,30]],"date-time":"2016-04-30T17:31:36Z","timestamp":1462037496000},"page":"16-41","source":"Crossref","is-referenced-by-count":26,"title":["Frederik Ruysch (1638\u20131731): Historical perspective and contemporary analysis of his teratological legacy"],"prefix":"10.1002","volume":"173","author":[{"given":"Lucas","family":"Boer","sequence":"first","affiliation":[{"name":"Department of Anatomy and Museum for Anatomy and Pathology Radboud University Medical Centre Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna B.","family":"Radziun","sequence":"additional","affiliation":[{"name":"Peter the Great Museum of Anthropology and Ethnography Russian Academy of Sciences Saint Petersburg Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roelof\u2010Jan","family":"Oostra","sequence":"additional","affiliation":[{"name":"Department of Anatomy Embryology and Physiology Academic Medical Center University of Amsterdam Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,4,29]]},"reference":[{"key":"e_1_2_6_2_1","volume-title":"Catalogus Musaei Ruyschiani, sive permagnae, elegantissimae, nitidissimae, incomparabilis et vere regiae collectionis","year":"1731"},{"key":"e_1_2_6_3_1","volume-title":"Musei Imperialis Petropolitani. Vol.I. Pars prima qua continentur res naturales ex regno animali","year":"1742"},{"key":"e_1_2_6_4_1","volume-title":"Catalogus van de uitmuntende cabinetten [\u2026] van den professor Ruysch [\u2026] met veel moeite en kosten in een reeks van jaaren vergadert en nagelaten door den heere Albertus Seba","year":"1751"},{"key":"e_1_2_6_5_1","volume-title":"Catalogus van de al\u00f6m beroemde kabinetten, bestaande in sierlyke anatomische praeparata, onder welke van den prof. F. Ruysch [\u2026] Alles by \u00e9\u00e9n vergadert en aldus nagelaten door den heer Adrianus Deknatel","year":"1765"},{"key":"e_1_2_6_6_1","volume-title":"Musei Gaubiani pars sive catalogus partis supellectis qua usus est vir celeberrimus H.D. Gaubius [\u2026]","year":"1783"},{"key":"e_1_2_6_7_1","volume-title":"Animalium musaei Houttuyniani index","year":"1787"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2431-7-2"},{"key":"e_1_2_6_9_1","first-page":"42","volume-title":"Dermoid and other cysts of the ovaries. Their origin from the Wolffian body","author":"Bandler SW","year":"1901"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000109216"},{"key":"e_1_2_6_11_1","first-page":"406","article-title":"Geburtsgeschichte und Untersuchung eines Falles von foetus in foeto","volume":"30","author":"Breslau RE","year":"1864","journal-title":"Zurich"},{"key":"e_1_2_6_12_1","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1542\/peds.67.5.721","article-title":"Gastric teratoma: Unusual cause for bleeding of the upper gastrointestinal tract in the newborn","volume":"67","author":"Cairo MS","year":"1981","journal-title":"Pediatrics"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1028-4559(08)60090-X"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4612-5628-1"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1700950134"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.15.82.65"},{"key":"e_1_2_6_17_1","first-page":"372","article-title":"Benign tumours of the stomach: Report of 27 cases","volume":"34","author":"Eustermann GB","year":"1922","journal-title":"Surg Gynecol Obstet"},{"key":"e_1_2_6_18_1","first-page":"953","volume-title":"Neoplastic diseases. A text book on tumors","author":"Ewing J","year":"1919"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1700880118"},{"key":"e_1_2_6_20_1","unstructured":"Geyl.1897. Betrachtungen \u00fcber die Genese der sogenannten Ovarialdermoide mit Bezug auf ein Vaginalteratom. Sammlung klinischer Vortr\u00e4ge von Volkmann. Neue Folge No. 190."},{"key":"e_1_2_6_21_1","first-page":"263","article-title":"Anatomicheskaia kollektsia F. Riuischa v sobraniiakh Petrovskoi Kunstkameri","volume":"14","author":"Ginzburg VV","year":"1953","journal-title":"Sbornik Museia Antropologii I Etnografii"},{"key":"e_1_2_6_22_1","first-page":"114","article-title":"Muzej kafedry normal'noi anatomii voenno\u2010meditsinskoi ordena Lenina Akademii im. S.M. Kirova. Archiv Anatomii","volume":"11","author":"Ginzburg VV","year":"1959","journal-title":"Gistologii I Embryologii Leningrad"},{"key":"e_1_2_6_23_1","first-page":"584","article-title":"Microperforate hymen in a primigravida in active labor: A case report","volume":"51","author":"Goto K","year":"2006","journal-title":"J Reprod Med"},{"key":"e_1_2_6_24_1","volume-title":"Anomalies and Curiosities of Medicine","author":"Gould GM","year":"1896"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-196411000-00018"},{"key":"e_1_2_6_26_1","first-page":"536","volume-title":"Bibliotheca Anatomica qua scripta ad anatomen et physiologiam facienta a rerum initiis recensentur","author":"Haller A von","year":"1774"},{"key":"e_1_2_6_27_1","first-page":"1","article-title":"Stuhltr\u00e4gheit Neugeborener in Folge von Dilatation und Hypertrophie des Colons","volume":"27","author":"Hirschsprung H","year":"1888","journal-title":"Jahrb Kinderheilk Phys Erzieh"},{"key":"e_1_2_6_28_1","volume-title":"Archives of Surgery. Vol. IV","author":"Hutchinson J","year":"1893"},{"key":"e_1_2_6_29_1","volume-title":"Handbuch der praktischen Zergliederungskunst: als Anleitung zu den Sections\u00fcbungen und zur Ausarbeitung anatomischer Pr\u00e4parate","author":"Hyrtl J","year":"1860"},{"key":"e_1_2_6_30_1","volume-title":"Vergangenheit und Gegenwart des Museums f\u00fcr menschlicheAnatomie an der Wiener Universit\u00e4t","author":"Hyrtl J","year":"1869"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.7863\/jum.2006.25.11.1495"},{"key":"e_1_2_6_32_1","first-page":"803","article-title":"La dilatation congenitale idiopatique du colon observ\u00e9e au XVIIe si\u00e8cle","volume":"17","author":"Jayle F","year":"1909","journal-title":"Presse Med"},{"key":"e_1_2_6_33_1","first-page":"370","volume-title":"The medico\u2010surgical review and the Journal of physical medicine","author":"Johnson J","year":"1840"},{"key":"e_1_2_6_34_1","volume-title":"Spicilegium Anatomicum, Continens Observationum Anatomicarum Rariorum Centuriam Unam, Nec Non Osteogeniam Foetuum","author":"Kerckring TT","year":"1670"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1091060205"},{"key":"e_1_2_6_36_1","volume-title":"De doodskunstenaar, de anatomische lessen van Frederik Ruysch","author":"Kooijmans L","year":"2004"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00583583"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2005.12.041"},{"key":"e_1_2_6_39_1","volume-title":"Trait\u00e9 des kystes cong\u00e9nitaux","author":"Lannelongue OM","year":"1886"},{"key":"e_1_2_6_40_1","unstructured":"LebertH.1852. Des kystes dermoides et de l'h\u00e9terotopie plastique en g\u00e9n\u00e9ral communiqu\u00e9 de la soci\u00e9t\u00e9 de biologie en ao\u00dbt I852. Gazette m\u00e9dicale de Paris 3me s\u00e9rie 7:720\u2013722 793\u2013796 808\u2013811."},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3468(70)90512-9"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.15.1782"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.brs.0000259834.28893.97"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1970.03170140077013"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00446428"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000152000.71369.bd"},{"key":"e_1_2_6_47_1","first-page":"306","article-title":"Dwarfism in the Amish. I. The Ellis\u2010 Van Creveld syndrome","volume":"115","author":"McKusick VA","year":"1964","journal-title":"Bull Johns Hopkins Hosp"},{"key":"e_1_2_6_48_1","first-page":"421","article-title":"\u00dcber die Divertikel am Darmkanal","volume":"9","author":"Meckel JF","year":"1809","journal-title":"Archiv f\u00fcr die Physiologie Halle"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmg.2005.01.029"},{"key":"e_1_2_6_50_1","volume-title":"\u00dcber die feineren Bau und die Formen der Krankhaften Geschw\u00fclste","author":"M\u00fcller J","year":"1838"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(28)90319-0"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/0046-8177(95)90232-5"},{"key":"e_1_2_6_53_1","first-page":"480","article-title":"Theodore Kerckring and his \u201cSpicilegium Anatomicum","volume":"42","author":"Nicholls AG","year":"1940","journal-title":"Can Med Assoc J"},{"key":"e_1_2_6_54_1","unstructured":"OllierLXEL.1890. Exostoses multiples. M\u00e9moires et comptes rendus de la Soci\u00e9t\u00e9 des sciences m\u00e9dicales de Lyon29:12."},{"key":"e_1_2_6_55_1","doi-asserted-by":"publisher","DOI":"10.1590\/1516-3180.2013.8012608"},{"key":"e_1_2_6_56_1","first-page":"78","volume-title":"The first scientific collections of Kunstkamera: Exhibition guide","author":"Radziun A","year":"2012"},{"key":"e_1_2_6_57_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-185X.2010.00135.x"},{"key":"e_1_2_6_58_1","volume-title":"Dilucidatio valvularum in vasis lymphaticis et lacteis cum figuris aeneis, accesserunt quaedam observations anatomicae rariores","author":"Ruysch F","year":"1665"},{"key":"e_1_2_6_59_1","volume-title":"Observationum anatomico\u2010chirurgicarum centuria, accredit catalogus rariorum quae in museo Ruyschiano asservantur","author":"Ruysch F","year":"1691"},{"key":"e_1_2_6_60_1","volume-title":"Musaeum anatomicum Ruyschianum, sive Catalogus rariorum, quae in authoris aedibus asservantur","author":"Ruysch F","year":"1691"},{"key":"e_1_2_6_61_1","volume-title":"Epistola anatomica, problematica decima. Auctore Bartholomaeo Keerwolff, med. doct. Ad virum clarissimum Fredericum Ruyschium de auricularum cordis, earumque fibrarum motricum structura","author":"Ruysch F","year":"1697"},{"key":"e_1_2_6_62_1","volume-title":"Epistola anatomica quarta & decima. Auctore Mauritio \u00e1 Reverhorst, med. doct et anat. professore. Ad virum clarissimum Fredericum Ruyschium de nova artuum decurtandorum method","author":"Ruysch F","year":"1701"},{"key":"e_1_2_6_63_1","volume-title":"Thesaurus anatomicus primus, cum figuris aeneis","author":"Ruysch F","year":"1701"},{"key":"e_1_2_6_64_1","volume-title":"Thesaurus anatomicus secundus, cum figuris aeneis","author":"Ruysch F","year":"1702"},{"key":"e_1_2_6_65_1","volume-title":"Thesaurus anatomicus tertius, cum figuris aeneis","author":"Ruysch F","year":"1703"},{"key":"e_1_2_6_66_1","volume-title":"Thesaurus anatomicus quartus, cum figuris aeneis","author":"Ruysch F","year":"1704"},{"key":"e_1_2_6_67_1","volume-title":"Thesaurus anatomicus sextus, cum figuris aeneis","author":"Ruysch F","year":"1705"},{"key":"e_1_2_6_68_1","volume-title":"Thesaurus anatomicus septimus, cum figuris aeneis","author":"Ruysch F","year":"1707"},{"key":"e_1_2_6_69_1","volume-title":"Thesaurus anatomicus octavus, cum figuris aeneis","author":"Ruysch F","year":"1709"},{"key":"e_1_2_6_70_1","volume-title":"Thesaurus anatomicus nonus, cum figuris aeneis","author":"Ruysch F","year":"1714"},{"key":"e_1_2_6_71_1","volume-title":"Thesaurus magnus et regius qui est decimus thesaurum anatomicorum in quo praecipuaecorporis humani partes, ceu in statu vivo, nitidissime praeparatae, reservatur, cum figuris aeneis","author":"Ruysch F","year":"1716"},{"key":"e_1_2_6_72_1","volume-title":"Adversariorum anatomico\u2010medico\u2010chirurgicorum decas prima, in qua varia notatu digna recensentur, cum figuris aeneis","author":"Ruysch F","year":"1717"},{"key":"e_1_2_6_73_1","volume-title":"Adversariorum anatomico\u2010medico\u2010chirurgicorum decas secunda, in qua varia notatu digna recensentur, cum figuris aeneis","author":"Ruysch F","year":"1720"},{"key":"e_1_2_6_74_1","volume-title":"Opera Omnia Anatomico\u2010Medico\u2010Chirurgica. Huc usque edita. quorum elenchus sequenti exhibetur, cum figuris aeneis","author":"Ruysch F","year":"1721"},{"key":"e_1_2_6_75_1","volume-title":"Adversariorum anatomico\u2010medico\u2010chirurgicorum decas tertia, in qua varia notatu digna recensentur, cum figuris aeneis","author":"Ruysch F","year":"1723"},{"key":"e_1_2_6_76_1","volume-title":"Tractatio anatomica de musculo in fundo uteri observato, ante hac a nemine detecto cui, accedit depulsionis secundinarum, parturientium foeminarum, instruction","author":"Ruysch F","year":"1723"},{"key":"e_1_2_6_77_1","volume-title":"Curae posteriores seu thesaurus anatomicus omnium praecedentium maximus, cum figuris aeneis","author":"Ruysch F","year":"1724"},{"key":"e_1_2_6_78_1","volume-title":"Curae renovatae seu thesaurus anatomicus, post curas posteriores, novus, cum figuris aeneis","author":"Ruysch F","year":"1728"},{"key":"e_1_2_6_79_1","volume-title":"Observations Anatomiques et Chirurgicales, au nombre de Cent par Mr. Fr\u00e9d\u00e9ric Ruysch, tr\u00e8s\u2010c\u00e9l\u00e8bre anatomiste. Avec des Figures en Taille\u2010douce qui repr\u00e9sentent les parties dans leur grandeur naturelle","author":"Ruysch F","year":"1734"},{"key":"e_1_2_6_80_1","volume-title":"Alle de Ontleed\u2010, Genees\u2010 en Heelkundige Werken","author":"Ruysch F","year":"1744"},{"key":"e_1_2_6_81_1","volume-title":"The Celebrated Dr. F. Ruysch's Practical Observations in Surgery and Midwifry. now first translated from the Latin Into English, by a Physician. Illustrated with Copper\u2010plates","author":"Ruysch F","year":"1751"},{"key":"e_1_2_6_82_1","first-page":"46","article-title":"Clinical genetics and pathobiology of ciliary chondrodysplasias","volume":"3","author":"Schmidts M","year":"2014","journal-title":"J Pediatr Genet"},{"key":"e_1_2_6_83_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01959357"},{"key":"e_1_2_6_84_1","unstructured":"SchwarzS.1999. Die anatomische Privatsammlung der Anatomenfamilie Meckel unter besonderer Ber\u00fccksichtigung ihres pr\u00e4parationstechnischen Profils. Thesis. Halle Martin\u2010L\u00fcther\u2010Universit\u00e4t Halle\u2010Wittenberg."},{"key":"e_1_2_6_85_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00491508"},{"key":"e_1_2_6_86_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420400102"},{"key":"e_1_2_6_87_1","unstructured":"TernowskyWN.1927. \u201cFredericus Ruysch\u201d aus dem Anatomischen Institut der Universit\u00e4t in Kasan. Bulletin du VI. Congres de la Soci\u00e9t\u00e9 Internationale d'Histoire de la M\u00e9dicine: 334\u2013338."},{"key":"e_1_2_6_88_1","volume-title":"Observationes medicae","author":"Tulp N","year":"1641"},{"key":"e_1_2_6_89_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-005-1404-y"},{"key":"e_1_2_6_90_1","volume-title":"Regii in Academia ad Albim musei anatomici Augustei Catalogus universalis","author":"Vater A","year":"1736"},{"key":"e_1_2_6_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-3782(85)90180-X"},{"key":"e_1_2_6_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(95)90197-3"}],"container-title":["American Journal of Medical Genetics Part A"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajmg.a.37663","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajmg.a.37663","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajmg.a.37663","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T14:59:20Z","timestamp":1696604360000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajmg.a.37663"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4,29]]},"references-count":91,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,1]]}},"alternative-id":["10.1002\/ajmg.a.37663"],"URL":"https:\/\/doi.org\/10.1002\/ajmg.a.37663","archive":["Portico"],"relation":{},"ISSN":["1552-4825","1552-4833"],"issn-type":[{"value":"1552-4825","type":"print"},{"value":"1552-4833","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,4,29]]}}}