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Intriguingly, there appears to be considerable variation in the rates of chromosome abnormality, with more recent studies typically reporting higher levels than those reported in early studies of spontaneous abortions. We were interested in examining the basis for these differences and accordingly, we reviewed studies of spontaneous abortions conducted in our laboratories over a 40\u2010year\u2010time span. Our analyses confirm a higher rate of abnormality in more recent series of spontaneous abortions, but indicate that the effect is largely, if not entirely, attributable to changes over time in the maternal age structures of the study populations. \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ajmg.a.37795","type":"journal-article","created":{"date-parts":[[2016,6,11]],"date-time":"2016-06-11T06:21:10Z","timestamp":1465626070000},"page":"2671-2680","source":"Crossref","is-referenced-by-count":88,"title":["Temporal changes in chromosome abnormalities in human spontaneous abortions: Results of 40 years of analysis"],"prefix":"10.1002","volume":"170","author":[{"given":"Kathy","family":"Hardy","sequence":"first","affiliation":[{"name":"Cyto Labs Pty Ltd. Perth Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip J.","family":"Hardy","sequence":"additional","affiliation":[{"name":"Cyto Labs Pty Ltd. 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