{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T05:41:39Z","timestamp":1761716499079,"version":"3.37.3"},"reference-count":26,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2016,9,8]],"date-time":"2016-09-08T00:00:00Z","timestamp":1473292800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000030","name":"Centers for Disease Control","doi-asserted-by":"crossref","award":["U50\/CCU913241"],"award-info":[{"award-number":["U50\/CCU913241"]}],"id":[{"id":"10.13039\/100000030","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J of Med Genetics Pt A"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:sec><jats:label\/><jats:p>We investigated whether orofacial clefts are associated with polymorphic variation within and around <jats:italic>FOXE1<\/jats:italic>. This California population\u2010based case control study focused on white Hispanic and white nonHispanic infants among which there were 262 infants with cleft lip with or without cleft palate (CL\/P), 103 with cleft palate only (CPO), and 382 unaffected controls. These cases and controls were genotyped for 13 SNPs across 220\u2009Kb at the <jats:italic>FOXE1<\/jats:italic> Locus. We observed associations with multiple <jats:italic>FOXE1<\/jats:italic> SNPs for CL\/P and for CPO, especially for the Hispanic study population. Increased risks were associated with the more common allele for all SNPs tested. Our results implicate <jats:italic>FOXE1<\/jats:italic> as an important locus whose polymorphic variation increases risks for all types of isolated clefts, and opens a new biological pathway to investigate in efforts to understand genetic factors underlying human clefting. \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ajmg.a.37871","type":"journal-article","created":{"date-parts":[[2016,9,8]],"date-time":"2016-09-08T12:13:20Z","timestamp":1473336800000},"page":"2770-2776","source":"Crossref","is-referenced-by-count":8,"title":["Genetic variation of <i>FOXE1<\/i> and risk for orofacial clefts in a California population"],"prefix":"10.1002","volume":"170","author":[{"given":"Edward J.","family":"Lammer","sequence":"first","affiliation":[{"name":"Children's Hospital Oakland Research Institute Oakland California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nebil","family":"Mohammed","sequence":"additional","affiliation":[{"name":"Children's 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