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This was accomplished by following 663 individuals with DS for 1 year, across five clinics in different states specializing in the comprehensive care of people with DS. Of the 663 participants, 114 individuals were screened for CD at their visit to a DS specialty clinic. Protracted constipation (43.2%) and refractory behavioral problems (23.7%) were symptoms most often reported to DS specialty providers. During the 1 year study period, 13 patients screened positive for CD by serology. Of those, eight underwent duodenal biopsy, and three were diagnosed with CD. We conclude that CD is an important consideration in the comprehensive care of individuals with DS. However, while symptoms are common, diagnoses are infrequent in DS specialty clinics. \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ajmg.a.37879","type":"journal-article","created":{"date-parts":[[2016,9,8]],"date-time":"2016-09-08T12:13:46Z","timestamp":1473336826000},"page":"3098-3105","source":"Crossref","is-referenced-by-count":16,"title":["Detecting celiac disease in patients with Down syndrome"],"prefix":"10.1002","volume":"170","author":[{"given":"Christianne","family":"Sharr","sequence":"first","affiliation":[{"name":"Down Syndrome Program, Division of Genetics, Department of Pediatrics Massachusetts General Hospital Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenifer","family":"Lavigne","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Clinical Genetics Levine Children's Hospital at Carolina Healthcare System Charlotte North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibrahim M. 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