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The daughters had 15 and 18 supernumerary teeth, respectively. The mother had normal dentition. Mutation analysis of <jats:italic>TRPS1<\/jats:italic> showed a novel heterozygous c.3809_3811delACTinsCATGTTGTG mutation in all. This mutation is predicted to cause amino acid changes in the Ikaros\u2010like zinc finger domain near the C\u2010terminal end of <jats:italic>TRPS1<\/jats:italic>, which is important for repressive protein function. The results of our study and the comprehensive review of the literature show that pathways of forming supernumerary teeth appear to involve <jats:italic>APC<\/jats:italic> and <jats:italic>RUNX2<\/jats:italic>, the genes responsible for familial adenomatous polyposis syndrome and cleidocranial dysplasia, respectively. 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