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Alterations of the <jats:italic>SATB2<\/jats:italic> gene can result from a variety of different mechanisms that include contiguous deletions, intragenic deletions and duplications, translocations with secondary gene disruption, and point mutations. The multisystemic nature of this syndrome demands a multisystemic approach and we propose evaluation and management guidelines. The <jats:italic>SATB2\u2010<\/jats:italic>associated syndrome registry has now been started and that will allow gathering further clinical information and refining the provided surveillance recommendations. \u00a9 2016 The Authors. <jats:italic>American Journal of Medical Genetics Part A<\/jats:italic> Published by Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ajmg.a.38022","type":"journal-article","created":{"date-parts":[[2016,10,24]],"date-time":"2016-10-24T06:13:04Z","timestamp":1477289584000},"page":"327-337","source":"Crossref","is-referenced-by-count":111,"title":["<i>SATB2<\/i>\u2010associated syndrome: Mechanisms, phenotype, and practical recommendations"],"prefix":"10.1002","volume":"173","author":[{"given":"Yuri A.","family":"Zarate","sequence":"first","affiliation":[{"name":"Section of Genetics and Metabolism University of Arkansas for Medical Sciences Little Rock Arkansas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer 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