{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T03:04:07Z","timestamp":1761102247713,"version":"3.37.3"},"reference-count":21,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,4,19]],"date-time":"2017-04-19T00:00:00Z","timestamp":1492560000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J of Med Genetics Pt A"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:sec><jats:label\/><jats:p>Neurofibromatosis type II (NF2) is a genetic disease characterized by bilateral vestibular schwannomas (VS) and other nerve system tumors. However, such tumors may be associated with environmental, rather than a genetic, etiology. Individuals fulfilling the clinical criteria of NF2 who had been treated by head ionized irradiation at a young age were compared for disease characteristics and molecular analysis with non\u2010irradiated sporadic NF2 cases. In the study cohort, three of 33 sporadic adult cases fulfilling NF2 diagnostic criteria had a history of early age cranial irradiation exposure. None of the irradiated patients had bilateral VS compared with 73.3% of the non\u2010irradiated individuals. One of the irradiated patients had no VS, while none of the non\u2010irradiated NF2 cases had absence of VS. All of the irradiated individuals had brain meningiomas and thyroid tumors compared with 47% and 0%, respectively, of the non\u2010irradiated individuals. Molecular analyses for NF2 mutations in blood of the irradiated individuals failed to detect disease\u2010causing mutations. This study suggest that environmental factors may mimic NF2. Identifying such non\u2010genetic cases fulfilling clinical criteria of the genetic disease may be crucial for the purposes of genetic counseling and patient management.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ajmg.a.38211","type":"journal-article","created":{"date-parts":[[2017,4,19]],"date-time":"2017-04-19T12:20:56Z","timestamp":1492604456000},"page":"1635-1639","source":"Crossref","is-referenced-by-count":1,"title":["Cranial irradiation in childhood mimicking neurofibromatosis type II"],"prefix":"10.1002","volume":"173","author":[{"given":"Felix","family":"Bokstein","sequence":"first","affiliation":[{"name":"The Gilbert Israeli Neurofibromatosis Center Tel\u2010Aviv Medical Center Tel\u2010Aviv Israel"},{"name":"Department of Oncology Tel\u2010Aviv Medical Center Tel\u2010Aviv Israel"},{"name":"Sackler Faculty of Medicine Tel\u2010Aviv University Tel\u2010Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tom","family":"Dubov","sequence":"additional","affiliation":[{"name":"Sackler Faculty of Medicine Tel\u2010Aviv University Tel\u2010Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hagit","family":"Toledano\u2010Alhadef","sequence":"additional","affiliation":[{"name":"The Gilbert Israeli Neurofibromatosis Center Tel\u2010Aviv Medical Center Tel\u2010Aviv Israel"},{"name":"Sackler Faculty of Medicine Tel\u2010Aviv University Tel\u2010Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rinat","family":"Bernstein\u2010Molho","sequence":"additional","affiliation":[{"name":"Department of Oncology Tel\u2010Aviv Medical Center Tel\u2010Aviv Israel"},{"name":"Sackler Faculty of Medicine Tel\u2010Aviv University Tel\u2010Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shlomi","family":"Constantini","sequence":"additional","affiliation":[{"name":"The Gilbert Israeli Neurofibromatosis Center Tel\u2010Aviv Medical Center Tel\u2010Aviv Israel"},{"name":"Sackler Faculty of Medicine Tel\u2010Aviv University Tel\u2010Aviv Israel"},{"name":"Department of Pediatric Neurosurgery Tel\u2010Aviv Medical Center Tel\u2010Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. Gareth","family":"Evans","sequence":"additional","affiliation":[{"name":"Genomic Medicine Manchester Academic Health Science Center Institute of Human Development Center Manchester NHS Foundation Trust Manchester Royal Infirmary University of Manchester Manchester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2628-8121","authenticated-orcid":false,"given":"Shay","family":"Ben\u2010Shachar","sequence":"additional","affiliation":[{"name":"The Gilbert Israeli Neurofibromatosis Center Tel\u2010Aviv Medical Center Tel\u2010Aviv Israel"},{"name":"Sackler Faculty of Medicine Tel\u2010Aviv University Tel\u2010Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,4,19]]},"reference":[{"issue":"4","key":"e_1_2_7_2_1","first-page":"135","article-title":"The possible relationship between small dose irradiation to the scalp and intracranial meningiomas","volume":"15","author":"Beller A. 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