{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T15:59:23Z","timestamp":1790179163953,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,4,19]],"date-time":"2017-04-19T00:00:00Z","timestamp":1492560000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004257","name":"Helse Vest","doi-asserted-by":"publisher","award":["911764"],"award-info":[{"award-number":["911764"]}],"id":[{"id":"10.13039\/501100004257","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005416","name":"Norges Forskningsr\u00e5d","doi-asserted-by":"publisher","award":["190858\/V50"],"award-info":[{"award-number":["190858\/V50"]}],"id":[{"id":"10.13039\/501100005416","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J of Med Genetics Pt A"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:sec>\n                    <jats:label\/>\n                    <jats:p>Congenital heart defects (CHD) constitute the largest group of congenital malformations. In most families, only one person has CHD; however, the risk of CHD increases for children born into families already affected. In this study, all births from 1994 through 2009 were identified in the Medical Birth Registry of Norway, including supplemental information on CHD from clinical and administrative registers, as part of the CVDNOR project. By using the unique personal identification number of each parent we were able to link 16,078 pairs of twins, 445,584 pairs of full siblings, and 106,840 pairs of half\u2010siblings. Sibling recurrence risk ratio (RRR) was calculated using CHD status in the oldest sibling as exposure and CHD status in the younger sibling as outcome, adjusted for year of birth, maternal age, and maternal diabetes. Among full sibling pairs with CHD in the older sibling, the younger sibling had CHD in 4.1% compared to 1.1% of the pairs without CHD in the older sibling (adjusted RRR 3.6; 95% confidence interval (CI) 3.1\u20134.1). In same\u2010sex twins the RRR was 14.0 (95% CI 10.6\u201318.6), and in opposite\u2010sex twins the RRR was 11.9 (95% CI 7.1\u201319.9). For half\u2010siblings the RRR was 1.5 (95% CI 0.8\u20132.8). When restricting to severe types of CHD, the RRR was 6.9 (95% CI 4.9\u20139.8) for full siblings. In 50% of the pairs with recurrent CHD, the siblings had similar types of CHD. The high relative risk of recurrence indicates that familial risk factors are important in the etiology of CHD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ajmg.a.38237","type":"journal-article","created":{"date-parts":[[2017,4,20]],"date-time":"2017-04-20T00:45:14Z","timestamp":1492649114000},"page":"1575-1585","source":"Crossref","is-referenced-by-count":39,"title":["Recurrence of congenital heart defects among siblings\u2014a nationwide study"],"prefix":"10.1002","volume":"173","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7518-310X","authenticated-orcid":false,"given":"Kristoffer","family":"Brodwall","sequence":"first","affiliation":[{"name":"Department of Global Public Health and Primary Care University of Bergen Bergen Norway"},{"name":"Department of Pediatrics Haukeland University Hospital Bergen Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gottfried","family":"Greve","sequence":"additional","affiliation":[{"name":"Department of Medical Science University of Bergen Bergen Norway"},{"name":"Department of Heart Disease Haukeland University Hospital Bergen Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Leirgul","sequence":"additional","affiliation":[{"name":"Department of Global Public Health and Primary Care University of Bergen Bergen Norway"},{"name":"Department of Heart Disease Haukeland University Hospital Bergen Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grethe S.","family":"Tell","sequence":"additional","affiliation":[{"name":"Department of Global Public Health and Primary Care University of Bergen Bergen Norway"},{"name":"Norwegian Institute of Public Health Bergen Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stein E.","family":"Vollset","sequence":"additional","affiliation":[{"name":"Department of Global Public Health and Primary Care University of Bergen Bergen Norway"},{"name":"Norwegian Institute of Public Health Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"\u00d8yen","sequence":"additional","affiliation":[{"name":"Department of Global Public Health and Primary Care University of Bergen Bergen Norway"},{"name":"Center for Medical Genetics and Molecular Medicine Haukeland University Hospital Bergen Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,4,19]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.326.7382.219"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a010297"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2015-307826"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.5694\/mja12.10811"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1058-9813(03)00084-5"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320260411"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-006-0295-9"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2004.05.018"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00008480-200110000-00014"},{"key":"e_1_2_10_11_1","unstructured":"EUROCAT.2014. 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