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The patients presented with variable developmental delays, exhibiting relative weaknesses in expressive language skills and relative strengths in gross, and fine motor skills. The most consistent facial features seen in these patients included a broad nasal root, a prominent forehead a prominent glabella and arched eyebrows. Additional variable features amongst the patients included microcephaly, metopic ridging or craniosynostosis, cleft palate, cardiac defects, and mild hypotonia. Although the patients\u2019 deletions varied in size, there was a 0.47\u2009Mb region of overlap which contained 7 OMIM genes: <jats:italic>EIP3B, CHST12, LFNG, BRAT1, TTYH3, AMZ1<\/jats:italic>, and <jats:italic>GNA12<\/jats:italic>. We propose that monosomy of this region represents a novel microdeletion syndrome. We recommend that individuals with 7p22.3p22.2 deletions should receive a developmental assessment and a thorough cardiac exam, with consideration of an echocardiogram, as part of their initial evaluation.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ajmg.a.38241","type":"journal-article","created":{"date-parts":[[2017,4,25]],"date-time":"2017-04-25T12:30:11Z","timestamp":1493123411000},"page":"1593-1600","source":"Crossref","is-referenced-by-count":11,"title":["Variable developmental delays and characteristic facial features\u2014A novel 7p22.3p22.2 microdeletion syndrome?"],"prefix":"10.1002","volume":"173","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3684-5112","authenticated-orcid":false,"given":"Andrea C.","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Genetics Children's Hospital of Eastern Ontario Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Regina 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