{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T06:10:53Z","timestamp":1793254253724,"version":"4.5.0"},"reference-count":78,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2017,7,7]],"date-time":"2017-07-07T00:00:00Z","timestamp":1499385600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J of Med Genetics Pt A"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:sec><jats:label\/><jats:p>The majority of studies describing demographics and co\u2010occurring conditions in cohorts with Down syndrome come from regions outside of the Middle East, mainly from Europe and North America. This paper describes demographics and co\u2010occurring conditions in a hospital\u2010based cohort of individuals with Down syndrome living in the Middle Eastern country of the United Arab Emirates (UAE). The first dedicated Down syndrome clinic in the UAE was established in 2012 at Tawam Hospital in Al Ain. This paper describes a clinic\u2010based cohort of 221 participants over 4 years from the Gulf Down Syndrome Registry, a new Down syndrome database and contact registry created at Tawam Hospital. Key demographic findings include mean maternal age of 37 years, among the highest described in the literature. Sixty\u2010two percent of mothers are &gt;35 years. Over 90% of mothers received post\u2010natal diagnosis of Down syndrome. High sex ratio, parental consanguinity, and large family size also characterize the group. The spectrum of many co\u2010occurring conditions mirrors that of previously described populations, with some notable differences. Cardiovascular malformations are well represented, however, atrioventricular canal is not the most common. Genitourinary conditions are common, as evidenced by 12% of males with hypospadias and 15% with undescended testes. Glucose\u20106\u2010phosphate dehydrogenase deficiency, alpha thalassemia trait, hypovitaminosis D, and dental caries are common in our cohort. This study describes a large hospital\u2010based group with Down syndrome presenting to a new dedicated Down syndrome clinic in the UAE, highlighting unique demographic and co\u2010occurring conditions found in that population.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ajmg.a.38338","type":"journal-article","created":{"date-parts":[[2017,7,7]],"date-time":"2017-07-07T14:23:42Z","timestamp":1499437422000},"page":"2395-2407","source":"Crossref","is-referenced-by-count":14,"title":["Demographics and co\u2010occurring conditions in a clinic\u2010based cohort with Down syndrome in the United Arab Emirates"],"prefix":"10.1002","volume":"173","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3629-566X","authenticated-orcid":false,"given":"Jennifer Price","family":"Corder","sequence":"first","affiliation":[{"name":"Department of Pediatrics Tawam Hospital in Affiliation With Johns Hopkins International Al Ain United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatima Jaber Sehmi","family":"Al Ahbabi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Tawam Hospital in Affiliation With Johns Hopkins International Al Ain United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hind Saif","family":"Al Dhaheri","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Tawam Hospital in Affiliation With Johns Hopkins International Al Ain United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fares","family":"Chedid","sequence":"additional","affiliation":[{"name":"Department of Neonatology Al Jalila Children's Specialty Hospital Dubai United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,7,7]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"Al Ain Medical District Human Research Ethics Committee Approval letter Protocol No. 14\/128\u2010CRD\/14. 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