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This variation is primarily attributed to methodology and classification differences. The distribution of associated anomalies among cases with congenital limb deficiencies in Alberta born between January 1, 1980 and December 31, 2012 is described. Of the 170 cases identified, most were live born (75.3%), male (61.8%), had longitudinal limb deficiencies (78.8%), and had associated anomalies outside the musculoskeletal system (77.6%). Significant associations between the preaxial longitudinal group and the central nervous, gastrointestinal, and cardiovascular systems are reported as well as between the postaxial longitudinal group and congenital hip and foot anomalies. Probable and possible syndrome diagnoses are described for cases with recognized malformation patterns.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ajmg.a.38513","type":"journal-article","created":{"date-parts":[[2017,11,23]],"date-time":"2017-11-23T05:34:43Z","timestamp":1511415283000},"page":"19-28","source":"Crossref","is-referenced-by-count":10,"title":["Congenital limb deficiencies and major associated anomalies in Alberta for the years 1980\u20132012"],"prefix":"10.1002","volume":"176","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5496-5084","authenticated-orcid":false,"given":"Tanya","family":"Bedard","sequence":"first","affiliation":[{"name":"Alberta Congenital Anomalies Surveillance System Alberta Health  Alberta Children's Hospital Calgary Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. Brian","family":"Lowry","sequence":"additional","affiliation":[{"name":"Alberta Congenital Anomalies Surveillance System Alberta Health  Alberta Children's Hospital Calgary Alberta Canada"},{"name":"Departments of Pediatrics and Medical Genetics University of Calgary Alberta Children's Hospital Calgary Alberta Canada"},{"name":"Alberta Children's Hospital Research Institute Calgary Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Sibbald","sequence":"additional","affiliation":[{"name":"Alberta Congenital Anomalies Surveillance System Alberta Health  Alberta Children's Hospital Calgary Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan","family":"Crawford","sequence":"additional","affiliation":[{"name":"Alberta Perinatal Health Program Calgary Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerhard N.","family":"Kiefer","sequence":"additional","affiliation":[{"name":"Alberta Congenital Anomalies Surveillance System Alberta Health  Alberta Children's Hospital Calgary Alberta Canada"},{"name":"Department of Surgery University of Calgary Alberta Children's Hospital Calgary Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,11,23]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.31612"},{"key":"e_1_2_8_3_1","unstructured":"Alberta Health Analytics and Performance Reporting. 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