{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T12:58:12Z","timestamp":1790081892897,"version":"4.0.1"},"reference-count":13,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,11,17]],"date-time":"2017-11-17T00:00:00Z","timestamp":1510876800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["K08NS078054"],"award-info":[{"award-number":["K08NS078054"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["K08NS089830"],"award-info":[{"award-number":["K08NS089830"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J of Med Genetics Pt A"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:sec><jats:label\/><jats:p><jats:italic>PURA<\/jats:italic>syndrome is a recently described developmental encephalopathy presenting with neonatal hypotonia, feeding difficulties, global developmental delay, severe intellectual disability, and frequent apnea and epilepsy. We describe 18 new individuals with heterozygous sequence variations in<jats:italic>PURA<\/jats:italic>. A neuromotor disorder starting with neonatal hyptonia, but ultimately allowing delayed progression to walking, was present in nearly all individuals. Congenital apnea was present in 56% during infancy, but all cases in this cohort resolved during the first year of life. Feeding difficulties were frequently reported, with gastrostomy tube placement required in 28%. Epilepsy was present in 50% of the subjects, including infantile spasms and Lennox\u2013Gastaut syndrome. Skeletal complications were found in 39%. Disorders of gastrointestinal motility and nystagmus were also recurrent features. Autism was diagnosed in one individual, potentially expanding the neurodevelopmental phenotype associated with this syndrome. However, we did not find additional<jats:italic>PURA<\/jats:italic>sequence variations in a cohort of 120 subjects with autism. We also present the first neuropathologic studies of<jats:italic>PURA<\/jats:italic>syndrome, and describe chronic inflammatory changes around the arterioles within the deep white matter. We did not find significant correlations between mutational class and severity, nor between location of the sequence variation in PUR repeat domains. Further studies are required in larger cohorts of subjects with<jats:italic>PURA<\/jats:italic>syndrome to clarify these genotype\u2013phenotype associations.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ajmg.a.38521","type":"journal-article","created":{"date-parts":[[2017,11,18]],"date-time":"2017-11-18T02:29:39Z","timestamp":1510972179000},"page":"56-67","source":"Crossref","is-referenced-by-count":43,"title":["Expanding the neurodevelopmental phenotype of<i>PURA<\/i>syndrome"],"prefix":"10.1002","volume":"176","author":[{"given":"Bo Hoon","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Neurology University of Rochester Medical Center Rochester New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margot R. 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