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Understanding the genetic and environmental factors contributing to the development of obesity in childhood is important for the rational design of strategies for obesity prevention and treatment. Brain\u2010derived neurotrophic factor (BDNF) plays an important role in the growth and development of the central nervous system, there is also an evidence that BDNF plays a role in regulation of appetite. Disruption of the expression of this gene in a child has been previously reported to result in a phenotype of severe obesity, hyperphagia, impaired cognitive function, and hyperactivity. We report a mother and child, both with micro\u2010deletions encompassing the BDNF gene locus, who both have obesity and developmental delay, although without hyperactivity. This report highlights the maternal inheritance of a rare genetic cause of childhood obesity.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ajmg.a.38539","type":"journal-article","created":{"date-parts":[[2017,11,21]],"date-time":"2017-11-21T05:37:36Z","timestamp":1511242656000},"page":"194-200","source":"Crossref","is-referenced-by-count":9,"title":["Maternal inheritance of BDNF deletion, with phenotype of obesity and developmental delay in mother and child"],"prefix":"10.1002","volume":"176","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0028-873X","authenticated-orcid":false,"given":"Brooke E.","family":"Harcourt","sequence":"first","affiliation":[{"name":"Obesity Research Murdoch Childrens Research Institute Parkville Australia"},{"name":"Department of Paediatrics Faculty of Medicine Dentistry and Health Sciences The University of Melbourne Parkville Australia"},{"name":"Department of Endocrinology and Diabetes The Royal Children's Hospital Melbourne Australia"},{"name":"Mater Research Institute\u2010UQ The University of Queensland Brisbane Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise V. 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