{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T09:56:24Z","timestamp":1756893384845,"version":"3.37.3"},"reference-count":23,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,1,24]],"date-time":"2018-01-24T00:00:00Z","timestamp":1516752000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["MOP nos. 97800","111238"],"award-info":[{"award-number":["MOP nos. 97800","111238"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J of Med Genetics Pt A"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:sec><jats:label\/><jats:p>22q11.2 deletion syndrome (22q11.2DS) is associated with high rates of anxiety disorders, psychotic disorders, and other psychiatric conditions. In the general population, psychiatric disorders are treated with proven pharmacological and non\u2010pharmacological therapies, such as cognitive behavioral therapy (CBT). To begin to assess the feasibility and efficacy of non\u2010pharmacological therapies in 22q11.2DS, we performed a systematic search to identify literature on non\u2010pharmacological interventions for psychiatric disorders in individuals with 22q11.2DS. Of 1,240 individual publications up to mid\u20102016 initially identified, 11 met inclusion criteria. There were five literature reviews, five publications reporting original research (two originating from a single study), and one publication not fitting either category that suggested adaptations to an intervention without providing scientific evidence. None of the original research involved direct study of the evidence\u2010based non\u2010pharmacological therapies available for psychiatric disorders. Rather, these four studies involved computer\u2010based or group interventions aimed at improving neuropsychological deficits that may be associated with psychiatric disorders. Although the sample sizes were relatively small (maximum 28 participants in the intervention group), these reports documented the promising feasibility of these interventions, and improvements in domains of neuropsychological functioning, including working memory, attention, and social cognition. The results of this review underline the need for research into the feasibility and efficacy of non\u2010pharmacological treatments of psychiatric disorders in individuals with 22q11.2DS to inform clinical care, using larger samples, and optimally, standard randomized, placebo\u2010controlled, clinical trials methodology.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ajmg.a.38612","type":"journal-article","created":{"date-parts":[[2018,1,24]],"date-time":"2018-01-24T12:26:42Z","timestamp":1516796802000},"page":"1742-1747","source":"Crossref","is-referenced-by-count":12,"title":["Non\u2010pharmacological treatment of psychiatric disorders in individuals with 22q11.2 deletion syndrome; a systematic review"],"prefix":"10.1002","volume":"176","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6370-7711","authenticated-orcid":false,"given":"Petra C. M.","family":"Buijs","sequence":"first","affiliation":[{"name":"The Dalglish Family 22q Clinic for Adults with 22q11.2 Deletion Syndrome University Health Network Toronto Ontario Canada"},{"name":"Kenter Jeugdhulp Child and Adolescent Mental Health Care Santpoort\u2010Noord The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0681-7279","authenticated-orcid":false,"given":"Anne S.","family":"Bassett","sequence":"additional","affiliation":[{"name":"The Dalglish Family 22q Clinic for Adults with 22q11.2 Deletion Syndrome University Health Network Toronto Ontario Canada"},{"name":"Clinical Genetics Research Program and Campbell Family Mental Health Research Institute Centre for Addiction and Mental Health Toronto Ontario Canada"},{"name":"Department of Psychiatry University of Toronto Toronto Ontario Canada"},{"name":"Department of Psychiatry University Health Network Toronto Ontario Canada"},{"name":"Institute of Medical Science University of Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0593-1539","authenticated-orcid":false,"given":"Erik","family":"Boot","sequence":"additional","affiliation":[{"name":"The Dalglish Family 22q Clinic for Adults with 22q11.2 Deletion Syndrome University Health Network Toronto Ontario Canada"},{"name":"De Hartekamp Groep Centre for People with Intellectual Disability Haarlem The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,1,24]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"American Psychiatric Association United States of America. Practice Guidelines.http:\/\/www.psychiatryonline.org\/guidelines"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2011.02.039"},{"issue":"1","key":"e_1_2_7_4_1","first-page":"19","article-title":"The effects of cognitive rehabilitation therapy techniques for enhancing the cognitive\/intellectual functioning of seventh\u2010 and eighth\u2010grade children","volume":"4","author":"Bracy O. D.","year":"1999","journal-title":"Cognitive Technology"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1024\/1422-4917.32.2.107"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmg.2016.09.007"},{"key":"e_1_2_7_7_1","first-page":"S46","article-title":"Evidence\u2010based program for improving socio\u2010emotional skills and executive function in children and adolescents with autism and developmental delay","volume":"1","author":"Eliez S.","year":"2015","journal-title":"European Child and Adolescent Psychiatry"},{"key":"e_1_2_7_8_1","first-page":"S86","article-title":"Socio\u2010emotional remediation for persons with autism spectrum disorder or other developmental disabilities","volume":"20","author":"Eliez S.","year":"2011","journal-title":"European Child and Adolescent Psychiatry"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1108\/AMHID-05-2014-0017"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2014.175"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2010.09101463"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1352\/1944-7558-117.5.368"},{"key":"e_1_2_7_13_1","first-page":"73","volume-title":"Educating children with velo\u2010cardio\u2010facial syndrome, also known as 22q11.2 deletion syndrome and DiGeorge syndrome","author":"Gothelf D.","year":"2013"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ridd.2013.05.009"},{"volume-title":"Cognitive enhancement therapy: The training manual","year":"2006","author":"Hogarty G. E.","key":"e_1_2_7_15_1"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/jir.12082"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/jir.12145"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2015.05.030"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2015.71"},{"key":"e_1_2_7_20_1","unstructured":". National Institute for Health and Care Excellence United Kingdom.https:\/\/www.nice.org.uk\/guidance"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2013.13070864"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/jir.12192"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291713001669"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajp.2011.03.002"}],"container-title":["American Journal of Medical Genetics Part A"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajmg.a.38612","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajmg.a.38612","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T02:37:23Z","timestamp":1695004643000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajmg.a.38612"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,24]]},"references-count":23,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2018,8]]}},"alternative-id":["10.1002\/ajmg.a.38612"],"URL":"https:\/\/doi.org\/10.1002\/ajmg.a.38612","archive":["Portico"],"relation":{},"ISSN":["1552-4825","1552-4833"],"issn-type":[{"type":"print","value":"1552-4825"},{"type":"electronic","value":"1552-4833"}],"subject":[],"published":{"date-parts":[[2018,1,24]]}}}