{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T23:23:43Z","timestamp":1792193023590,"version":"4.4.0"},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,2,9]],"date-time":"2018-02-09T00:00:00Z","timestamp":1518134400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J of Med Genetics Pt A"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:sec><jats:label\/><jats:p>Achondroplasia is the most common form of inherited disproportionate short stature. We report leg length, sitting height, and body proportion curves for achondroplasia. Seven centile format of sitting height, leg length, sitting height\/leg length ratio, sitting height\/height ratio, and head circumference\/height ratio were estimated by the LMS method. The Q\u2010test was applied to assess the goodness of fit. For comparison, centiles of sitting height and leg length were graphed using Argentine national growth references for achondroplasia and non\u2010achondroplasia populations. The sample consisted of 342 children with achondroplasia (171 males, 171 females) aged 0\u201318 years. The median (interquartile range) number of measurements per child was 6 (3, 12) for sitting height and 8 (3, 13) for head circumference. Median leg length increased from 14\u2009cm at age 1 week to 44 and 40\u2009cm (males and females, respectively) in achondroplasia adolescents which is 3.5\u2009cm shorter than non\u2010achondroplasia children at age 1 week and, 38\u2009cm shorter at adolescence. Median sitting height increased from 34\u2009cm at birth to 86 and 81 in adolescents\u2019 boys and girls respectively, only 5\u2009cm shorter than non\u2010achondroplasia children. Sitting height\/leg length decreased from 2.61 at birth to approximately 1.90 at adolescent. Median head circumference\/height ratio decreased from 0.79 at birth to 0.46 at 18 years in both sexes. Growth of lower limbs is affected early in life and becomes more noticeable throughout childhood. The disharmonic growth between the less affected trunk and the severely affected limbs determine body disproportion in achondroplasia.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ajmg.a.38633","type":"journal-article","created":{"date-parts":[[2018,2,9]],"date-time":"2018-02-09T06:29:05Z","timestamp":1518157745000},"page":"896-906","source":"Crossref","is-referenced-by-count":29,"title":["Leg length, sitting height, and body proportions references for achondroplasia: New tools for monitoring growth"],"prefix":"10.1002","volume":"176","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6095-7080","authenticated-orcid":false,"given":"Mariana","family":"del Pino","sequence":"first","affiliation":[{"name":"Growth and Development Pediatric Garrahan Hospital Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosario","family":"Ramos Mej\u00eda","sequence":"additional","affiliation":[{"name":"Growth and Development Pediatric Garrahan Hospital Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia","family":"Fano","sequence":"additional","affiliation":[{"name":"Growth and Development Pediatric Garrahan Hospital Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,2,9]]},"reference":[{"issue":"2","key":"e_1_2_8_2_1","first-page":"368","article-title":"Achondroplasia is defined by recurrent G380R mutations of FGFR3","volume":"56","author":"Bellus G. 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