{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T13:02:48Z","timestamp":1762002168010,"version":"build-2065373602"},"reference-count":56,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,2,9]],"date-time":"2018-02-09T00:00:00Z","timestamp":1518134400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004586","name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro","doi-asserted-by":"publisher","award":["E\u201009\/226.368\/2016"],"award-info":[{"award-number":["E\u201009\/226.368\/2016"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["306396\/2013\u20100","400427\/2013\u20103","440614\/2016\u20103"],"award-info":[{"award-number":["306396\/2013\u20100","400427\/2013\u20103","440614\/2016\u20103"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J of Med Genetics Pt A"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:sec><jats:label\/><jats:p>We compared Brazilian oral cleft (OC) frequencies between the population\u2010based Brazilian System of Live Birth (SINASC) and the hospital\u2010based Latin American Collaborative Study of Congenital Malformations (ECLAMC), trying to understand the paucity of cleft of lip and palate (CLP) in the first system. SINASC uses the International Classification of Disease version 10 (ICD\u201010) for congenital defects coding, ECLAMC uses ICD\u20108 with modifications. In SINASC, the CLP frequency was 1.7 per 10,000 (95% confidence limits 1.7\u20131.8), cleft lip (CL) 1.6 (1.5\u20131.7), and cleft palate (CP) 2.0 (1.9\u20132.1). In ECLAMC, the CLP frequency was 10.4 per 10,000 (9.0\u201312.1), CL 5.5 (4.5\u20136.7), and CP 4.4. (4.5\u20136.7). In SINASC, only 33% of the oral clefts were CLP, versus 51% in ECLAMC. Part of this discrepancy may have been due to the relative excess of CP and CL cases. Although congenital defect frequencies are usually lower in population than in hospital\u2010based registries, differences in the proportion of the main OC categories are not expected and are probably due to ICD\u201010 coding issues, such as lumping of unilateral CL and CL without other specifications. ICD\u201010 codes, whose deficiency for oral clefts is fully explained in the literature, lack modifiers for severity, or clinical subtypes. This paper shows the practical aspect of the ICD\u201010 system deficiency in capturing cleft lip and palate (CLP) subtypes, as demonstrated in SINASC covering three million births per year. Such errors are expected to occur in any registry that uses the ICD\u201010 coding system, and must be adjusted, given its relevance worldwide.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ajmg.a.38634","type":"journal-article","created":{"date-parts":[[2018,2,9]],"date-time":"2018-02-09T13:59:07Z","timestamp":1518184747000},"page":"907-914","source":"Crossref","is-referenced-by-count":9,"title":["ICD\u201010 impact on ascertainment and accuracy of oral cleft cases as recorded by the Brazilian national live birth information system"],"prefix":"10.1002","volume":"176","author":[{"given":"Ricardo Lima","family":"do Nascimento","sequence":"first","affiliation":[{"name":"Department of Genetics Institute of Biology Federal University of Rio de Janeiro Rio de Janeiro Brazil"},{"name":"INAGEMP (National Institute of Population Medical Genetics) Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo E.","family":"Castilla","sequence":"additional","affiliation":[{"name":"INAGEMP (National Institute of Population Medical Genetics) Rio de Janeiro Brazil"},{"name":"LEMC (Laboratory of Congenital Malformations Epidemiology) Oswaldo Cruz Institute Oswaldo Cruz Foundation Rio de Janeiro Brazil"},{"name":"CEMIC (Center for Medical Education and Clinical Research) Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria da Gra\u00e7a","family":"Dutra","sequence":"additional","affiliation":[{"name":"INAGEMP (National Institute of Population Medical Genetics) Rio de Janeiro Brazil"},{"name":"LEMC (Laboratory of Congenital Malformations Epidemiology) Oswaldo Cruz Institute Oswaldo Cruz Foundation Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1863-6229","authenticated-orcid":false,"given":"I\u00eada M.","family":"Orioli","sequence":"additional","affiliation":[{"name":"Department of Genetics Institute of Biology Federal University of Rio de Janeiro Rio de Janeiro Brazil"},{"name":"INAGEMP (National Institute of Population Medical Genetics) Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,2,9]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.23528"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1597\/03-034.1"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.23544"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1597\/15-219"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1597\/14-080"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1754-4505.1994.tb01072.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.23415"},{"key":"e_1_2_7_9_1","first-page":"213","article-title":"Cleft palate in Montana: A 10\u2010year report","volume":"6","author":"Bardanouve V. 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