{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T04:44:15Z","timestamp":1790397855372,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,4,21]],"date-time":"2018-04-21T00:00:00Z","timestamp":1524268800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100005440","name":"Center for Scientific Review","doi-asserted-by":"publisher","award":["RR\u201003\u2010008"],"award-info":[{"award-number":["RR\u201003\u2010008"]}],"id":[{"id":"10.13039\/100005440","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J of Med Genetics Pt A"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:p>Prader\u2013Willi syndrome (PWS) is caused by a deficiency of imprinted genes in the 15q11\u2010q13 region and is characterized by prenatal onset of hypotonia, poor feeding, childhood\u2010onset obesity, hyperphagia, short stature, facial dysmorphism, intellectual disability, and behavioral problems. We studied perinatal factors in a cohort of 64 people with PWS resulting from paternal deletion of 15q11\u2010q13 and maternal uniparental disomy (UPD) for chromosome 15. We recruited 34 individuals with deletion and 30 with UPD. We compared the frequency of multiple prenatal and neonatal factors with the general population as well as between the two genetic subtypes. Of the 64 individuals with PWS, fetal movements were decreased in 82.8%, 31.7% were born prematurely, 42.1% by Cesarean section, and 35.9% required oxytocin induction. Apgar scores were low in 34.6%, 96.8% had feeding difficulty, 50% needed tube feeding, and 6.2% subsequently had gastrostomy tube placement. On comparing findings in the deletion versus the UPD groups, we did not find many significant differences. We, however, found a higher maternal age, and also later age at diagnosis in the UPD versus the deletion group. PWS subjects have higher rates of perinatal complications, especially Cesarean section rate, hypotonia, and low Apgar scores compared to the general population. We did not find many differences between the genetic subtypes, except for later age of diagnosis of the UPD 15 group suggesting a milder phenotype. We also found that the mothers in the UPD were older, supporting the hypothesis that UPD results from nondisjunction associated trisomy rescue.<\/jats:p>","DOI":"10.1002\/ajmg.a.38679","type":"journal-article","created":{"date-parts":[[2018,4,22]],"date-time":"2018-04-22T00:10:11Z","timestamp":1524355811000},"page":"1161-1165","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Comparison of perinatal factors in deletion versus uniparental disomy in Prader\u2013Willi syndrome"],"prefix":"10.1002","volume":"176","author":[{"given":"June\u2010Anne","family":"Gold","sequence":"first","affiliation":[{"name":"Division of Genetics and Genomic Medicine, Department of Pediatrics University of California Irvine California"},{"name":"Division of Genetics and Metabolism, Department of Pediatrics Loma Linda University Loma Linda California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ranim","family":"Mahmoud","sequence":"additional","affiliation":[{"name":"Division of Genetics and Genomic Medicine, Department of Pediatrics University of California Irvine California"},{"name":"Genetics Unit, Department of Pediatrics, Faculty of Medicine Mansoura University Mansoura Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne B.","family":"Cassidy","sequence":"additional","affiliation":[{"name":"Division of Genetics and Genomic Medicine, Department of Pediatrics University of California Irvine California"},{"name":"Division of Medical Genetics, Department of Pediatrics University of California San Francisco California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1567-4449","authenticated-orcid":false,"given":"Virginia","family":"Kimonis","sequence":"additional","affiliation":[{"name":"Division of Genetics and Genomic Medicine, Department of Pediatrics University of California Irvine California"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,4,21]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-017-0673-6"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.4914"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/gim.0b013e31822bead0"},{"key":"e_1_2_9_5_1","unstructured":"Center for Disease Control and Prevention. (1980\u20132003).Vital Statistics of the United States: 1980\u20132003. Retrieved fromhttps:\/\/www.cdc.gov\/nchs\/products\/vsus\/vsus_1980_2003.htm"},{"issue":"3","key":"e_1_2_9_6_1","first-page":"191","article-title":"Does the genetic cause of Prader\u2010Willi syndrome explain the highly variable phenotype?","volume":"11","author":"Dobrescu A. I.","year":"2016","journal-title":"Maedica (Buchar)"},{"key":"e_1_2_9_7_1","unstructured":"D. J. Driscoll J. L. Miller S. 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