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The study aimed to assess the functional independence in children with PWS. The Functional Independence Measure for Children (WeeFIM) was used to evaluate 81 children with PWS (44 boys and 37 girls) with a median age of 11 years 1 month (range 2 years 8 months to 20 years 2 months) were recruited between January 2013 and December 2016. The mean total WeeFIM score was 103.8 (maximum 126). Sixty\u2010five patients (80%) had deletion type PWS, 16 (20.0%) had nondeletion type. The scores were 103.6\u2009\u00b1\u200918.5 for deletion and 104.8\u2009\u00b1\u200918.3 for nondeletion type (<jats:italic>p<\/jats:italic>\u2009=\u2009.405), 104.8\u2009\u00b1\u200919.3 in boys and 102.6\u2009\u00b1\u200917.3 in girls (<jats:italic>p<\/jats:italic>\u2009=\u2009.293). The mean self\u2010care, mobility, and cognition scores were 47 (maximum 56), 33 (maximum 35), and 24 (maximum 35), respectively. All total scores and 18 subscores in the three functional domains were positively correlated with age (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05). Most children required assistance in problem\u2010solving, comprehension, and expression. 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