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Poor cognitive functioning and intellectual disabilities, attention and executive functioning deficits, learning disorders, emotional dysregulation and impairments in social processing are common among individuals with 22q11.2 DS. Identifying risk and protective\/resilience factors that can be detected in early life and can predict neurodevelopmental outcomes for people with 22q11.2 DS is of significant clinical relevance and might allow for early detection and intervention. Given the focus of this review, we will discuss the possible contributing factors that influence the neurodevelopmental outcome in 22q1.2 DS, the cognitive phenotype in 22q11.2 DS, the different developmental trajectories across life span, and the implications for clinical practice and management.<\/jats:p>","DOI":"10.1002\/ajmg.a.38709","type":"journal-article","created":{"date-parts":[[2018,4,26]],"date-time":"2018-04-26T02:27:56Z","timestamp":1524709676000},"page":"2160-2166","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Neurodevelopmental outcome in 22q11.2 deletion syndrome and management"],"prefix":"10.1002","volume":"176","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4258-4537","authenticated-orcid":false,"given":"Ann","family":"Swillen","sequence":"first","affiliation":[{"name":"Department of Human Genetics KU Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward","family":"Moss","sequence":"additional","affiliation":[{"name":"Children's Hospital of Philadelphia Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sasja","family":"Duijff","sequence":"additional","affiliation":[{"name":"University Medical Centre Utrecht Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,4,25]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ddrr.7"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.30984"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2011.02.039"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1076\/jcen.23.4.447.1228"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2012.66"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1017\/CBO9780511544101.009"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.116.195651"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2013.71"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2788.2007.00955.x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cortex.2007.06.003"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ddrr.44"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.111.097139"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2014.175"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19990716)85:2<127::AID-AJMG6>3.0.CO;2-F"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1352\/1944-7558-117.5.368"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2002.124774"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1572"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/CHI.0b013e3181b76683"},{"key":"e_1_2_8_20_1","first-page":"1","article-title":"Neurocognitive development in 22q11.2 deletion syndrome: Comparison with youth having developmental delay and medical comorbidities","volume":"2014","author":"Gur R. 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