{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T16:48:26Z","timestamp":1780591706970,"version":"3.54.1"},"reference-count":37,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2018,9,4]],"date-time":"2018-09-04T00:00:00Z","timestamp":1536019200000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["1Z01AG000666\u20100"],"award-info":[{"award-number":["1Z01AG000666\u20100"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J of Med Genetics Pt A"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:p>The objective of this study was to explore the factors contributing to quality of life in pediatric patients with non\u2010vascular Ehlers\u2013Danlos syndromes (EDS). Data were analyzed on 41 children with a diagnosis of non\u2010vascular EDS from the de\u2010identified data available from the National Institute on Aging (NIA) study of heritable disorders of connective tissue. Children under age 19 years were seen as part of a long\u2010term evaluation project from 2003 to 2013 on a larger natural history of patients with heritable disorders of connective tissue. Data collected included medical history, physical examination findings, diagnostic study results, and responses on validated questionnaires. We reviewed a sub\u2010cohort of children with a diagnosis of non\u2010vascular EDS and explored pain severity and interference via the Brief Pain Inventory, and sleep quality via the Pittsburgh Sleep Quality Index. Pain severity had a strong correlation with pain interference, and both were similar to other disorders that include chronic pain reported in the literature. Sleep quality did not correlate with pain severity or interference, but all patients had poor sleep quality in comparison to historical controls. We conclude that pain and sleep are significant issues in the pediatric non\u2010vascular EDS population, and future research may be directed toward these issues.<\/jats:p>","DOI":"10.1002\/ajmg.a.40371","type":"journal-article","created":{"date-parts":[[2018,9,4]],"date-time":"2018-09-04T11:03:41Z","timestamp":1536059021000},"page":"1858-1864","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Pain and sleep quality in children with non\u2010vascular Ehlers\u2013Danlos syndromes"],"prefix":"10.1002","volume":"176","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0386-7622","authenticated-orcid":false,"given":"Michael","family":"Muriello","sequence":"first","affiliation":[{"name":"The Johns Hopkins University School of Medicine  Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia L.","family":"Clemens","sequence":"additional","affiliation":[{"name":"The Johns Hopkins University School of Medicine  Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiyi","family":"Mu","sequence":"additional","affiliation":[{"name":"The Johns Hopkins University School of Medicine  Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phuong T.","family":"Tran","sequence":"additional","affiliation":[{"name":"Ho Chi Minh City University of Technology\u2010HUTECH  Ho Chi Minh City Vietnam"},{"name":"Johns Hopkins Bloomberg School of Public Health  Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter C.","family":"Rowe","sequence":"additional","affiliation":[{"name":"The Johns Hopkins University School of Medicine  Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christy H.","family":"Smith","sequence":"additional","affiliation":[{"name":"The Johns Hopkins University School of Medicine  Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clair","family":"Francomano","sequence":"additional","affiliation":[{"name":"Greater Baltimore Medical Center  Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joann","family":"Bodurtha","sequence":"additional","affiliation":[{"name":"The Johns Hopkins University School of Medicine  Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7863-2994","authenticated-orcid":false,"given":"Antonie D.","family":"Kline","sequence":"additional","affiliation":[{"name":"Greater Baltimore Medical Center  Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,9,4]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-014-2610-6"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep33902"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/813867"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19980428)77:1<31::AID-AJMG8>3.0.CO;2-O"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1781(89)90047-4"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.31425"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.36315"},{"issue":"2","key":"e_1_2_6_9_1","first-page":"129","article-title":"Pain assessment: global use of the Brief Pain Inventory","volume":"23","author":"Cleeland C. S.","year":"1994","journal-title":"Annals of the Academy of Medicine, Singapore"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kew032"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-010-1729-2"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2011-300440"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.4103\/0972-2327.44559"},{"issue":"7","key":"e_1_2_6_14_1","first-page":"1777","article-title":"The revised (Brighton 1998) criteria for the diagnosis of benign joint hypermobility syndrome (BJHS)","volume":"27","author":"Grahame R.","year":"2000","journal-title":"The Journal of Rheumatology"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2007.08.153"},{"key":"e_1_2_6_16_1","first-page":"1","article-title":"Features that exacerbate fatigue severity in joint hypermobility syndrome\/Ehlers\u2013Danlos syndrome \u2013 hypermobility type","volume":"9","author":"Krahe A. M.","year":"2017","journal-title":"Disability and Rehabilitation"},{"key":"e_1_2_6_17_1","first-page":"1","article-title":"CDC growth charts: United States","volume":"314","author":"Kuczmarski R. J.","year":"2000","journal-title":"Advance Data"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1348\/135910703762879237"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2008.150839"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijnurstu.2010.10.007"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.31552"},{"key":"e_1_2_6_22_1","unstructured":"Mandel K.W. Griwold C.A. Francomano C.A. &McDonnell N.B.(2006 October.). Study of Sleep Disturbance in Ehlers\u2010Danlos Sleep Disturbance in Ehlers\u2010Danlos Syndromes: Related to Chronic Pain or an Independent Entity? Abstract presented at the annual meeting of The American Society of Human Genetics New Orleans Louisiana."},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.3109\/03009742.2012.676064"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1080\/15402002.2013.764528"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpc.12826"},{"key":"e_1_2_6_26_1","first-page":"CD008325","article-title":"Back schools for acute and subacute non\u2010specific low\u2010back pain","volume":"26","author":"Poquet N.","year":"2016","journal-title":"The Cochrane Database of Systematic Reviews"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.22998"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kex148"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12969-015-0014-z"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2016.10.078"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2003.12.005"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.33070"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.37836"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2009.12.026"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2009.08.003"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physio.2010.06.001"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-013-1193-1"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2007.07.025"}],"container-title":["American Journal of Medical Genetics Part A"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajmg.a.40371","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajmg.a.40371","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ajmg.a.40371","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajmg.a.40371","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T15:47:58Z","timestamp":1694360878000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajmg.a.40371"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9]]},"references-count":37,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2018,9]]}},"alternative-id":["10.1002\/ajmg.a.40371"],"URL":"https:\/\/doi.org\/10.1002\/ajmg.a.40371","archive":["Portico"],"relation":{},"ISSN":["1552-4825","1552-4833"],"issn-type":[{"value":"1552-4825","type":"print"},{"value":"1552-4833","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9]]},"assertion":[{"value":"2018-01-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-05-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-09-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}