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The available treatments for BSyn are symptomatic, and early identification of complications has the potential to improve outcomes. To accomplish this, standardized recommendations for health supervision are needed for early diagnosis and treatment. The purpose of this report is to use information from the BSyn Registry, published literature, and expertise from clinicians and researchers with experience in BSyn to develop recommendations for diagnosis, screening, and treatment of the clinical manifestations in people with BSyn. These health supervision recommendations can be incorporated into the routine clinical care of people with BSyn and can be revised as more knowledge is gained regarding their clinical utility.<\/jats:p>","DOI":"10.1002\/ajmg.a.40374","type":"journal-article","created":{"date-parts":[[2018,7,29]],"date-time":"2018-07-29T07:28:07Z","timestamp":1532849287000},"page":"1872-1881","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":61,"title":["Health supervision for people with Bloom syndrome"],"prefix":"10.1002","volume":"176","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6041-477X","authenticated-orcid":false,"given":"Christopher","family":"Cunniff","sequence":"first","affiliation":[{"name":"Division of Medical Genetics, Department of Pediatrics Weill Cornell Medical College  New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir Reza","family":"Djavid","sequence":"additional","affiliation":[{"name":"Division of Medical Genetics, Department of Pediatrics Weill Cornell Medical College  New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Carrubba","sequence":"additional","affiliation":[{"name":"Division of Medical Genetics, Department of Pediatrics Weill Cornell Medical College  New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Cohen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Johns Hopkins University School of Medicine  Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan A.","family":"Ellis","sequence":"additional","affiliation":[{"name":"Department of Cellular and Molecular Medicine University of Arizona Cancer Center  Tucson Arizona"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolyn Fein","family":"Levy","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology, Department of Pediatrics Hofstra Northwell School of Medicine  Hempstead New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stacy","family":"Jeong","sequence":"additional","affiliation":[{"name":"Division of Medical Genetics, Department of Pediatrics Weill Cornell Medical College  New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard M.","family":"Lederman","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Johns Hopkins University School of Medicine  Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Vogiatzi","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Diabetes Children's Hospital of Philadelphia  Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael F.","family":"Walsh","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Memorial Sloan Kettering Cancer Center  New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann Graham","family":"Zauber","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics Memorial Sloan Kettering Cancer Center  New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,7,28]]},"reference":[{"key":"e_1_2_15_2_1","doi-asserted-by":"publisher","DOI":"10.4172\/2157-7412.1000177"},{"key":"e_1_2_15_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0928-8244(03)00304-3"},{"key":"e_1_2_15_4_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.182.1.347"},{"key":"e_1_2_15_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-014-3624-5"},{"key":"e_1_2_15_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0929-693X(96)82165-8"},{"key":"e_1_2_15_7_1","first-page":"754","article-title":"Congenital telangiectatic erythema resembling lupus erythematosus in dwarfs","volume":"88","author":"Bloom D.","year":"1954","journal-title":"American Journal of Diseases of Children"},{"key":"e_1_2_15_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)93017-4"},{"key":"e_1_2_15_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(87)80469-9"},{"key":"e_1_2_15_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1437"},{"key":"e_1_2_15_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000093826"},{"key":"e_1_2_15_12_1","volume-title":"GeneReviews\u00ae","author":"Dome J. 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