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A literature search of trisomy 18 patients with reports of tumors or malignancies, and compilation of all previously reported as well as new unreported cases was performed. 67 patients with trisomy 18 were found to have documented malignancies. 44 patients had hepatoblastomas, 21 patients had Wilms tumors, one patient had a functional neurogenic neoplasia, and one patient had Hodgkins lymphoma. The increasing numbers of reported malignancies in patients with trisomy 18 supports the indication for an early screening process. Specific screening recommendations are outlined consisting of imaging exams and laboratory values performed at specific intervals.<\/jats:p>","DOI":"10.1002\/ajmg.a.61029","type":"journal-article","created":{"date-parts":[[2019,1,14]],"date-time":"2019-01-14T05:18:06Z","timestamp":1547443086000},"page":"455-466","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Solid tumor screening recommendations in trisomy 18"],"prefix":"10.1002","volume":"179","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0225-6291","authenticated-orcid":false,"given":"Shannon G.","family":"Farmakis","sequence":"first","affiliation":[{"name":"Department of Radiology Saint Louis University School of Medicine and SSM Health Cardinal Glennon Children's Hospital  St. Louis Missouri"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ann M.","family":"Barnes","sequence":"additional","affiliation":[{"name":"The Support Organization for Trisomy 18, 13 and Related Disorders  Rochester New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6007-8518","authenticated-orcid":false,"given":"John C.","family":"Carey","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Utah  Salt Lake City Utah"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen R.","family":"Braddock","sequence":"additional","affiliation":[{"name":"Division of Medical Genetics, Department of Pediatrics Saint Louis University School of Medicine and SSM Cardinal Glennon Children's Hospital  St. Louis Missouri"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,1,13]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"499","article-title":"Autopsy of hepatoblastoma with trisomy 18","volume":"46","author":"Abe T.","year":"1983","journal-title":"Journal Pediatric Practice"},{"key":"e_1_2_7_3_1","first-page":"1149","article-title":"Autopsy of hepatoblastoma with trisomy 18","volume":"87","author":"Abe T.","year":"1983","journal-title":"Journal Japanese Pediatric Society"},{"key":"e_1_2_7_4_1","first-page":"1","article-title":"Hepatoblastoma in a mosaic trisomy 18 child with hemihypertrophy","volume":"2016","author":"Ahmad N.","year":"2016","journal-title":"BMJ Case Reports"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.20141"},{"key":"e_1_2_7_6_1","first-page":"373","article-title":"Large hepatoblastoma in a girl with trisomy 18","volume":"29","author":"Ariwa R.","year":"1992","journal-title":"Japanese Journal of Pediatric Oncology"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.62.4.362"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/15513819609169287"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.31523"},{"key":"e_1_2_7_10_1","first-page":"74A","article-title":"Increased risk of Wilms tumor in children with trisomy 18: The evidence and recommendations for a surveillance protocol","volume":"21","author":"Carey J. 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