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EDS is a set of heritable connective tissue disorders with high symptom burden, including chronic pain. Prescription medication use among persons with EDS was compared to a cohort of matched controls using 10 years of administrative claims data from a large database of privately insured patients (2005\u20132014). Our dataset included 4,294 persons with EDS, ages 5\u201362\u2009years old. In both adults and children, we found that the percentage of persons with a prescription drug claim was higher in the EDS cohort for all prescription drug classes examined. Among children, opioid use was double in the EDS cohort compared to the control group (27.5% vs. 13.5%); in adults, it was nearly double in EDS patients (62% vs. 34.1%). Among persons who were prescribed opioids, those with EDS had higher cumulative dosages over a 2\u2010year time period versus controls. Our study aids in understanding opioid and prescription drug use patterns in a vulnerable population with high symptom burden and chronic pain that is often severe.<\/jats:p>","DOI":"10.1002\/ajmg.a.61031","type":"journal-article","created":{"date-parts":[[2019,1,9]],"date-time":"2019-01-09T12:36:19Z","timestamp":1547037379000},"page":"397-403","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Use of prescription opioid and other drugs among a cohort of persons with Ehlers\u2013Danlos syndrome: A retrospective study"],"prefix":"10.1002","volume":"179","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9334-6892","authenticated-orcid":false,"given":"Jane R.","family":"Schubart","sequence":"first","affiliation":[{"name":"Department of Surgery The Pennsylvania State University, College of Medicine  Hershey Pennsylvania"},{"name":"Department of Public Health Sciences The Pennsylvania State University, College of Medicine  Hershey Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amber","family":"Schilling","sequence":"additional","affiliation":[{"name":"Department of Surgery The Pennsylvania State University, College of Medicine  Hershey Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Schaefer","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences The Pennsylvania State University, College of Medicine  Hershey Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Bascom","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences The Pennsylvania State University, College of Medicine  Hershey Pennsylvania"},{"name":"Department of Medicine The Pennsylvania State University, College of Medicine  Hershey Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clair","family":"Francomano","sequence":"additional","affiliation":[{"name":"Ehlers\u2013Danlos Society Center for Clinical Care and Research, Greater Baltimore Medical Center  Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,1,9]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.97105s2531"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19980428)77:1<31::AID-AJMG8>3.0.CO;2-O"},{"key":"e_1_2_6_4_1","unstructured":"Bergsralh D. 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