{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T03:46:09Z","timestamp":1761709569683,"version":"3.40.5"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,1,13]],"date-time":"2019-01-13T00:00:00Z","timestamp":1547337600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"The Focus Foundation"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J of Med Genetics Pt A"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:p>47,XXY (Klinefelter syndrome) is the most common X and Y chromosomal variation (1:660 males). The incidence of anxiety disorders and the impact of hormonal replacement therapy (HRT) is not well understood. Child Behavior Checklist and Screen for Childhood Anxiety Related Emotional Disorders were completed by parents of 80 boys with 47,XXY. Forty received HRT prior to 10 years of age while 40 did not. HRT (22.5%) received early hormonal treatment prior to 18\u2009months. About 32.5% received hormone booster treatment between 5 and 10 years. The remaining 42.5% received both. There were fewer reported social (<jats:italic>p<\/jats:italic>\u2009=\u2009.015), thought (<jats:italic>p<\/jats:italic>\u2009=\u2009.012), and affective problems (<jats:italic>p<\/jats:italic>\u2009=\u2009.048) in treated boys when compared to untreated. Boys with both treatments demonstrated fewer symptoms on anxious\/depressed scale (<jats:italic>p\u2009=<\/jats:italic> .001) compared to those with early treatment only. Within the treated group, prenatally diagnosed showed fewer indications of anxiety problems (<jats:italic>p<\/jats:italic>\u2009=\u2009.02) than their postnatal counterparts. This comparative, cross\u2010sectional study expands previous findings on the possible positive effect of HRT in boys with 47,XXY. Anxiety disorders appear to be a penetrant aspect of the 47,XXY phenotype. Further investigation is warranted to explore the relationship between biological treatment and individual responses to HRT to develop more personalized and precise medicine.<\/jats:p>","DOI":"10.1002\/ajmg.a.61038","type":"journal-article","created":{"date-parts":[[2019,1,14]],"date-time":"2019-01-14T05:20:06Z","timestamp":1547443206000},"page":"423-428","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["The incidence of anxiety symptoms in boys with 47,XXY (Klinefelter syndrome) and the possible impact of timing of diagnosis and hormonal replacement therapy"],"prefix":"10.1002","volume":"179","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9941-0568","authenticated-orcid":false,"given":"Carole","family":"Samango\u2010Sprouse","sequence":"first","affiliation":[{"name":"George Washington University, Department of Pediatrics  Washington, DC"},{"name":"Children's National Health System, Neurodevelopmental Pediatrics and Neurogenetics  Washington, DC"},{"name":"Florida International University, Department of Human and Molecular Genetics  Miami Florida"},{"name":"The Focus Foundation  Davidsonville Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia","family":"Lasutschinkow","sequence":"additional","affiliation":[{"name":"The Focus Foundation  Davidsonville Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sherida","family":"Powell","sequence":"additional","affiliation":[{"name":"George Washington University, Department of Pediatrics  Washington, DC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teresa","family":"Sadeghin","sequence":"additional","affiliation":[{"name":"The Focus Foundation  Davidsonville Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Gropman","sequence":"additional","affiliation":[{"name":"George Washington University, Department of Pediatrics  Washington, DC"},{"name":"Children's National Health System, Neurodevelopmental Pediatrics and Neurogenetics  Washington, DC"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,1,13]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1542\/pir.21.8.265"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00354965"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004583-199910000-00011"},{"key":"e_1_2_5_5_1","first-page":"1","article-title":"Mental health surveillance among children\u2014United States, 2005\u20132011","volume":"62","author":"Centers for Disease Control and Prevention","year":"2013","journal-title":"MMWR"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-2834"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000232162"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0148-9062(75)90418-0"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-031624"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)16678-6"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/000992289103000305"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2012.06.001"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci7090113"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01213097"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.54.12.2218"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-69644-2_2"},{"issue":"4","key":"e_1_2_5_17_1","first-page":"59","article-title":"Sex chromosome aneuploidy: The Denver prospective study","volume":"26","author":"Robinson A.","year":"1991","journal-title":"Birth Defects Original Article Series"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2017.02.036"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2011-0719"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.32232"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1159\/000087313"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001163-200207000-00004"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.31353"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.31437"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.38621"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.35769"},{"issue":"2","key":"e_1_2_5_27_1","first-page":"138","article-title":"Advances in research on the neurological and neuropsychiatric phenotype of Klinefelter syndrome","volume":"25","author":"Savic I.","year":"2012","journal-title":"Neurology"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.GIM.0000095626.54201.D0"},{"key":"e_1_2_5_29_1","unstructured":"Sprouse C. Stapleton E. Sdeghin T. Gropman A. &Samango\u2010Sprouse C. (2013).The effects of early hormonal replacement on the anthropometric measurements of boys with XXY. Poster presented at 16thSSBP International Research Symposium Stellenbosch South Africa."},{"key":"e_1_2_5_30_1","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1542\/peds.59.4.574","article-title":"The early childhood developmental of 17 boys with sex chromosome anomalies: A prospective study","volume":"59","author":"Tennes K.","year":"1977","journal-title":"Pediatrics"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/gbb.12203"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10803-013-1860-5"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10803-008-0542-1"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.31350"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.clinpsy.3.022806.091358"}],"container-title":["American Journal of Medical Genetics Part A"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajmg.a.61038","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajmg.a.61038","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ajmg.a.61038","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajmg.a.61038","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T20:41:52Z","timestamp":1693946512000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajmg.a.61038"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,13]]},"references-count":34,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,3]]}},"alternative-id":["10.1002\/ajmg.a.61038"],"URL":"https:\/\/doi.org\/10.1002\/ajmg.a.61038","archive":["Portico"],"relation":{},"ISSN":["1552-4825","1552-4833"],"issn-type":[{"type":"print","value":"1552-4825"},{"type":"electronic","value":"1552-4833"}],"subject":[],"published":{"date-parts":[[2019,1,13]]},"assertion":[{"value":"2018-05-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-12-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-01-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}