{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T02:25:07Z","timestamp":1790130307699,"version":"4.0.1"},"reference-count":32,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,3,25]],"date-time":"2019-03-25T00:00:00Z","timestamp":1553472000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["1 R13NS10342101"],"award-info":[{"award-number":["1 R13NS10342101"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J of Med Genetics Pt A"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:p>The neurofibromatoses are inherited, tumor suppressor disorders that are characterized by multiple, benign peripheral nerve sheath tumors and other nervous system tumors. Each disease is associated with a distinct genetic mutation and with a different pathogenesis and clinical course. Neurofibromatosis 1 (NF1) is common and epitomized by multiple neurofibromas with widespread complications. NF2 and schwannomatosis are rare diseases that are typified by multiple schwannomas that are particularly painful in people with schwannomatosis. Since 1985, the Children's Tumor Foundation (formerly the National Neurofibromatosis Foundation) has hosted an international Neurofibromatosis Conference, bringing together international participants who are focused on NF research and clinical care. The 2017 Conference, held in Washington, DC, was among the largest gatherings of NF researchers to date and included presentations from clinicians and basic scientists, highlighting new data regarding the molecular and cellular mechanisms underlying each of these diseases as well as results from clinical studies and clinical trials. This article summarizes the findings presented at the meeting and represents the current state\u2010of\u2010the art for NF research.<\/jats:p>","DOI":"10.1002\/ajmg.a.61112","type":"journal-article","created":{"date-parts":[[2019,3,25]],"date-time":"2019-03-25T18:27:54Z","timestamp":1553538474000},"page":"1098-1106","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["From process to progress\u20142017 International Conference on Neurofibromatosis 1, Neurofibromatosis 2 and Schwannomatosis"],"prefix":"10.1002","volume":"179","author":[{"given":"Rosalie E.","family":"Ferner","sequence":"first","affiliation":[{"name":"Department of Neurology, Neurofibromatosis Centre Guy's and St. Thomas' NHS Foundation Trust, and King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette","family":"Bakker","sequence":"additional","affiliation":[{"name":"Children's Tumor Foundation  New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ype","family":"Elgersma","sequence":"additional","affiliation":[{"name":"Department of Neuroscience Erasmus Medical Center  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. Gareth R.","family":"Evans","sequence":"additional","affiliation":[{"name":"Centre for Genomic Medicine St. Mary's Hospital  Manchester UK"},{"name":"Manchester Academic Health Sciences Centre (MAHSC), Division of Evolution and Genomic Science University of Manchester  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Giovannini","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery University of California  Los Angeles"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Legius","sequence":"additional","affiliation":[{"name":"Department of Human Genetics University Hospital Leuven  Leuven Herestraat Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison","family":"Lloyd","sequence":"additional","affiliation":[{"name":"Laboratory for Molecular Cell Biology University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludwine M.","family":"Messiaen","sequence":"additional","affiliation":[{"name":"Medical Genomics Laboratory, Department of Genetics University of Alabama  Birmingham Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Plotkin","sequence":"additional","affiliation":[{"name":"Department of Neurology and Cancer Center, Massachusetts General Hospital Harvard Medical School  Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karlyne M.","family":"Reilly","sequence":"additional","affiliation":[{"name":"Rare Tumors Initiative, Center for Cancer Research National Institutes of Health  Bethesda Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron","family":"Schindeler","sequence":"additional","affiliation":[{"name":"Orthopaedic Research &amp; Biotechnology The Children's Hospital at Westmead  Westmead New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam J.","family":"Smith","sequence":"additional","affiliation":[{"name":"Centre for Genomic Medicine St. Mary's Hospital  Manchester UK"},{"name":"Manchester Academic Health Sciences Centre (MAHSC), Division of Evolution and Genomic Science University of Manchester  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole J.","family":"Ullrich","sequence":"additional","affiliation":[{"name":"Department of Neurology, Boston Children's Hospital Harvard Medical School  Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigitte","family":"Widemann","sequence":"additional","affiliation":[{"name":"Pediatric Oncology Branch, Center for Cancer Research National Cancer Institute  Bethesda Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6098-6551","authenticated-orcid":false,"given":"Larry S.","family":"Sherman","sequence":"additional","affiliation":[{"name":"Division of Neuroscience, Oregon National Primate Research Center, and Department of Cell, Developmental and Cancer Biology Oregon Health &amp; Science University  Portland Oregon"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,3,25]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3688"},{"issue":"3","key":"e_1_2_6_3_1","first-page":"609","article-title":"Distinct structural characteristics of discoidin I subfamily receptor tyrosine kinases and complementary expression in human cancer","volume":"10","author":"Alves F.","year":"1995","journal-title":"Oncogene"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41388-018-0328-7"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-16-0821"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNO.0000000000000550"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2018-318538"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.33139"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clineuro.2017.05.002"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/noy013"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2010.10.041"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-018-1909-9"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2017.12.001"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2014.05.001"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.4161\/cc.9.22.13838"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1369\/0022155417729357"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2016.2600"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2015.48"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2014.220"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40246-017-0109-3"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cortex.2017.04.022"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11682-017-9717-8"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djx124"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3348"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-014-0082-1"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0055119"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2011.11.013"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddx423"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2017.10.012"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2014.465"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-00346-5"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/humu.23421"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1719966115"}],"container-title":["American Journal of Medical Genetics Part A"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajmg.a.61112","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ajmg.a.61112","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajmg.a.61112","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T21:57:16Z","timestamp":1694296636000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajmg.a.61112"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,25]]},"references-count":32,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,6]]}},"alternative-id":["10.1002\/ajmg.a.61112"],"URL":"https:\/\/doi.org\/10.1002\/ajmg.a.61112","archive":["Portico"],"relation":{},"ISSN":["1552-4825","1552-4833"],"issn-type":[{"value":"1552-4825","type":"print"},{"value":"1552-4833","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3,25]]},"assertion":[{"value":"2018-12-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-02-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-03-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}