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The RASopathies are a group of syndromes caused by germline mutations in genes that encode components of the RAS\/mitogen\u2010activated protein kinase (MAPK) pathway. The RASopathies include NF1, Noonan syndrome, Noonan syndrome with multiple lentigines, Costello syndrome, cardio\u2010facio\u2010cutaneous syndrome, Legius syndrome, capillary malformation arterio\u2010venous malformation syndrome, and SYNGAP1 autism. Due to their common underlying pathogenetic etiology, all these syndromes have significant phenotypic overlap of which one common feature include a predisposition to tumors, which may be benign or malignant. Together as a group, they represent one of the most common multiple congenital anomaly syndromes estimating to affect approximately one in 1000 individuals worldwide. The subcontinent of India represents one of the largest populations in the world, yet remains underserved from an aspect of clinical genetics services. In an effort to bridge this gap, the <jats:italic>First International Conference on RASopathies and Neurofibromatoses in Asia: Identification and Advances of New Therapeutics<\/jats:italic> was held in Kochi, Kerala, India. These proceedings chronicle this timely and topical international symposium directed at discussing the best practices and therapies for individuals with neurofibromatoses and RASopathies.<\/jats:p>","DOI":"10.1002\/ajmg.a.61125","type":"journal-article","created":{"date-parts":[[2019,3,25]],"date-time":"2019-03-25T19:26:21Z","timestamp":1553541981000},"page":"1091-1097","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["First International Conference on RASopathies and Neurofibromatoses in Asia: Identification and advances of new therapeutics"],"prefix":"10.1002","volume":"179","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1719-7228","authenticated-orcid":false,"given":"Katherine A.","family":"Rauen","sequence":"first","affiliation":[{"name":"Department of Pediatics, Division of Genomic Medicine University of California Davis  Sacramento California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abeer","family":"Alsaegh","sequence":"additional","affiliation":[{"name":"Genetics Department Sultan Qaboos University and Hospital  Muscat Oman"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2628-8121","authenticated-orcid":false,"given":"Shay","family":"Ben\u2010Shachar","sequence":"additional","affiliation":[{"name":"Genetics Institute Tel\u2010Aviv Sourasky Medical Center  Tel\u2010Aviv Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yemima","family":"Berman","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics Royal North Shore Hospital  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaishri","family":"Blakeley","sequence":"additional","affiliation":[{"name":"Department of Neurology Johns Hopkins University School of Medicine  Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Cordeiro","sequence":"additional","affiliation":[{"name":"Hospital Santa Maria  Lisbon Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ype","family":"Elgersma","sequence":"additional","affiliation":[{"name":"Department of Neuroscience Erasmus University Medical Center  Rotterdam Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. 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