{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T07:29:15Z","timestamp":1793777355814,"version":"4.6.1"},"reference-count":30,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,5,15]],"date-time":"2019-05-15T00:00:00Z","timestamp":1557878400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J of Med Genetics Pt A"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Isolated postaxial polydactyly (I\u2010PAP), as a single defect, is a frequent malformation, characterized by an extra digit placed on the ulnar or fibular side of the limbs. Worldwide prevalence varies from as high as 225\/10,000 in Nigerians to so low as 6.08\/10,000 in Argentinians. Genetic\u2013ethnic background significantly affects worldwide prevalence and type of I\u2010PAP. Herein we describe the epidemiological characteristics of I\u2010PAP in 697 newborns, 383 males and 314 females identified in 1,178,993 examined live births from a multicenter case\u2013control hospital\u2010based population study, the Mexican program of Registry and Epidemiological Surveillance of Congenital Malformations (RYVEMCE). The main characteristics analyzed included total I\u2010PAP, stratified in Types A and B, defined as complete or incomplete extra\u2010digit formation, respectively, sex prevalence, affected limb, laterality, parity, prematurity, delivery\u2010type, twinning, consanguinity, and parental age. Males (6.35\/10,000) are significantly more frequently affected than females (5.45\/10,000), hands more than feet, left more than right limbs, and Type B (74.50%) more than A (25.50%). Prematurity and forceps use were significantly more frequent in cases than controls. An evident decreasing time\u2010trend prevalence was present. Similar findings with other studies were males, upper and left limbs more frequently affected. Findings that were not previously reported include prematurity, forceps use, a significant decreasing time trend and an inverse ethnic prevalence for Types A (75%) and B (25%) in the Mayan population in contrast to other worldwide ethnic groups.<\/jats:p>","DOI":"10.1002\/ajmg.a.61193","type":"journal-article","created":{"date-parts":[[2019,5,15]],"date-time":"2019-05-15T14:55:27Z","timestamp":1557932127000},"page":"1432-1441","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Isolated postaxial polydactyly: Epidemiologic characteristics from a multicenter birth defects study"],"prefix":"10.1002","volume":"179","author":[{"given":"Gabriela","family":"Ortiz\u2010Cruz","sequence":"first","affiliation":[{"name":"Department of Genetics Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n M\u00e9xico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonora","family":"Luna\u2010Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"Department of Genetics Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n M\u00e9xico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jazm\u00edn","family":"Arteaga\u2010V\u00e1zquez","sequence":"additional","affiliation":[{"name":"Department of Genetics Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n M\u00e9xico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4886-0045","authenticated-orcid":false,"given":"Osvaldo M.","family":"Mutchinick","sequence":"additional","affiliation":[{"name":"Department of Genetics Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n M\u00e9xico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,5,15]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/1753193407087888"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.22609"},{"issue":"1","key":"e_1_2_6_4_1","first-page":"91","article-title":"Polydactyly in the American Indian","volume":"27","author":"Bingle G. 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