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It is also present in a high percentage of patients with intellectual and developmental disabilities, such as Cri du chat (CdC) syndrome, a rare genetic disorder caused by variable size deletions of the short arm of chromosome 5. The aim of this study was to evaluate, in 97 patients with CdC syndrome, the following data: frequency of SP, patient's age at onset, type, and topographic\u2013anatomic distribution of the lesions presented. The results show that 85% of patients confirm a SP disorder, usually concentrated on the hands, fingers, and the face, with onset between 6 and 10 years of age, regardless of patient's sex. Evidence for early appearance of SP behavior, high prevalence in stressful circumstances, and efficacy of distracting actions immediately suggest the possibility that proper parental information about SP behavior and parental education concerning the methods to deal with this problem may result in its efficient reduction already in childhood.<\/jats:p>","DOI":"10.1002\/ajmg.a.61259","type":"journal-article","created":{"date-parts":[[2019,6,12]],"date-time":"2019-06-12T12:18:47Z","timestamp":1560341927000},"page":"1525-1530","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Skin picking disorder in 97 Italian and Spanish Cri du chat patients"],"prefix":"10.1002","volume":"179","author":[{"given":"Marianna","family":"Spunton","sequence":"first","affiliation":[{"name":"SOC Pediatria Ospedale Castelli Verbania Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Guala","sequence":"additional","affiliation":[{"name":"SOC Pediatria Ospedale Castelli Verbania Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria E.","family":"Liverani","sequence":"additional","affiliation":[{"name":"SOC Pediatria Ospedale Sant\u2032 Andrea Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luisa","family":"Medolago","sequence":"additional","affiliation":[{"name":"Associazione Bambini Cri du Chat (ABC) Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabio","family":"Tognon","sequence":"additional","affiliation":[{"name":"Associazione Bambini Cri du Chat (ABC) Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F\u00e9lix","family":"Casado","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n S\u00edndrome 5p Espa\u00f1a Alacant Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"del Valle","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n S\u00edndrome 5p Espa\u00f1a Alacant Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josefina","family":"Porras","sequence":"additional","affiliation":[{"name":"Asociaci\u00f3n Nacional de Afectados por el S\u00edndrome del Maullido del Gato (ASIMAGA) Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabel","family":"Larrea","sequence":"additional","affiliation":[{"name":"Asociaci\u00f3n Nacional de Afectados por el S\u00edndrome del Maullido del Gato (ASIMAGA) Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Porta","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine University of Insubria Varese Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Albani","sequence":"additional","affiliation":[{"name":"Divisione di Neurologia e Neuro\u2010Riabilitazione IRCCS Istituto Auxologico Italiano, Ospedale San Giuseppe Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julian","family":"Nevado","sequence":"additional","affiliation":[{"name":"Structural and Functional Genomics Section, Instituto de Gen\u00e9tica M\u00e9dica y Molecular (INGEMM) Hospital Universitario la PAZ\u2010IdiPaz, Centro de Investigaci\u00f3n B\u00e1sica de Investigaci\u00f3n en Red de Enfermedades Raras (CIBERER) Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8400-5671","authenticated-orcid":false,"given":"Cesare","family":"Danesino","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine IRCCS Policlinico San Matteo, University of Pavia Pavia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,6,12]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2010.226"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2788.2010.01337.x"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-1-33"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2788.2002.00361.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.75.5.448"},{"issue":"11","key":"e_1_2_5_7_1","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1111\/j.1469-8749.1997.tb07377.x","article-title":"Correlates of maladaptive behaviour in individuals with Cri du chat syndrome","volume":"39","author":"Dykens E. 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