{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T14:22:11Z","timestamp":1747146131265,"version":"3.40.5"},"reference-count":27,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,6,21]],"date-time":"2019-06-21T00:00:00Z","timestamp":1561075200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J of Med Genetics Pt A"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Prader\u2010Willi syndrome (PWS) is generally due to sporadic paternal deletions of the chromosome 15q11\u2010q13 region followed by maternal disomy 15. Advanced maternal age is more commonly seen in those with maternal disomy 15. Environmental factors (e.g., drug use, occupational chemical exposure, infectious agents, and irradiation) could account for chromosome changes. Previous evidence of differences in male and female gametogenesis could suggest an environmental role in the causation of the paternal 15q11\u2010q13 deletion seen in PWS. Certain occupations such as hydrocarbon\u2010exposing occupations (e.g., landscaping, farming, and painting) and viral exposure (e.g., human coronavirus 229E causing upper respiratory infections in adults with an incorporation site in the human genome at chromosome 15q11) can be seasonal in nature and contribute to chromosome damage. To assess, we reviewed birth seasonality data in a large cohort of individuals with PWS recruited nationally (<jats:italic>N<\/jats:italic> = 355) but no significant differences were seen by month between those with the 15q11\u2010q13 deletion compared with maternal disomy 15 when analyzing quarterly seasonal patterns. Although early evidence supported birth seasonality differences in PWS, a larger number of individuals in our recent study using advanced genetic testing methods did not find this observation.<\/jats:p>","DOI":"10.1002\/ajmg.a.61263","type":"journal-article","created":{"date-parts":[[2019,6,21]],"date-time":"2019-06-21T12:33:51Z","timestamp":1561120431000},"page":"1531-1534","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Birth seasonality studies in a large Prader\u2013Willi syndrome cohort"],"prefix":"10.1002","volume":"179","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2911-0524","authenticated-orcid":false,"given":"Merlin G.","family":"Butler","sequence":"first","affiliation":[{"name":"Department of Psychiatry, Behavioral Sciences and Pediatrics University of Kansas Medical Center  Kansas City Kansas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1567-4449","authenticated-orcid":false,"given":"Virginia","family":"Kimonis","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of California  Irvine California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabeth","family":"Dykens","sequence":"additional","affiliation":[{"name":"Vanderbilt Kennedy Center for Research on Human Development Vanderbilt University  Nashville Tennessee"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"June Anne","family":"Gold","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Loma Linda University Medical School  Loma Linda California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roy","family":"Tamura","sequence":"additional","affiliation":[{"name":"Health Informatics Institute, University of South Florida College of Medicine  Tampa Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer L.","family":"Miller","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Florida College of Medicine  Gainesville Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel J.","family":"Driscoll","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Florida College of Medicine  Gainesville Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,6,21]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.1995.tb11971.x"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.35893"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1218(82)90148-3"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.pmbts.2015.12.003"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmedgenet-2018-105301"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.38582"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(85)90811-6"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-33536-0"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-009-9341-7"},{"key":"e_1_2_4_11_1","first-page":"806","article-title":"Occupational hydrocarbon exposure among fathers of Prader\u2010Willi syndrome patients with and without deletions of 15q","volume":"44","author":"Cassidy S. 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