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The Stanford Binet and Wechsler (WAIS\u2010R; WISC\u2010III) intelligence (IQ) tests were administered on 103 individuals with PWS from two separate cohorts [University of California, Irvine (UCI) (<jats:italic>N<\/jats:italic> = 56) and Vanderbilt University (<jats:italic>N<\/jats:italic> = 47)] and clinical information obtained including growth hormone (GH) treatment, PWS molecular classes, weight and height. Significantly higher IQ scores (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.02) were found representing the vocabulary section of the Stanford Binet test in the growth hormone (GH) treated group when compared with non\u2010GH treatment in the pediatric\u2010based UCI PWS cohort with a trend for stabilization of vocabulary IQ scores with age in the GH treated maternal disomy (UPD) 15 subject group. Significant differences (<jats:italic>p<\/jats:italic> = .05) were also found in the adult\u2010based Vanderbilt PWS cohort with 15q11\u2010q13 deletion subjects having lower Verbal IQ scores compared with UPD 15. No difference in body mass index was identified based on the PWS molecular class or genetic subtype. Medical care and response to treatment with growth hormone may influence intelligence impacted by PWS genetic subtypes and possibly age, but more studies are needed.<\/jats:p>","DOI":"10.1002\/ajmg.a.61293","type":"journal-article","created":{"date-parts":[[2019,7,17]],"date-time":"2019-07-17T06:00:21Z","timestamp":1563343221000},"page":"1826-1835","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Impact of genetic subtypes of Prader\u2013Willi syndrome with growth hormone therapy on intelligence and body mass index"],"prefix":"10.1002","volume":"179","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2911-0524","authenticated-orcid":false,"given":"Merlin G.","family":"Butler","sequence":"first","affiliation":[{"name":"Division of Research and Genetics Department of Psychiatry and Behavioral Sciences, University of Kansas Medical Center  Kansas City Kansas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naomi A.","family":"Matthews","sequence":"additional","affiliation":[{"name":"Division of Genetics and Genomic Medicine, Department of Pediatrics University of California  Irvine California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nidhi","family":"Patel","sequence":"additional","affiliation":[{"name":"Division of Genetics and Genomic Medicine, Department of Pediatrics University of California  Irvine California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abhilasha","family":"Surampalli","sequence":"additional","affiliation":[{"name":"Division of Genetics and Genomic Medicine, Department of Pediatrics University of California  Irvine California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"June\u2010Anne","family":"Gold","sequence":"additional","affiliation":[{"name":"Division of Genetics and Genomic Medicine, Department of Pediatrics University of California  Irvine California"},{"name":"Division of Genetics and Metabolism, Department of Pediatrics University of Loma Linda  Loma Linda California"},{"name":"Children's Hospital of Orange County  Orange California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manaswitha","family":"Khare","sequence":"additional","affiliation":[{"name":"Division of Genetics and Genomic Medicine, Department of Pediatrics University of California  Irvine California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Travis","family":"Thompson","sequence":"additional","affiliation":[{"name":"Department of Educational Psychology University of Minnesota  Twin Cities Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzanne B.","family":"Cassidy","sequence":"additional","affiliation":[{"name":"Division of Genetics and Genomic Medicine, Department of Pediatrics University of California  Irvine California"},{"name":"Division of Medical Genetics, Department of Pediatrics University of California  San Francisco California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1567-4449","authenticated-orcid":false,"given":"Virginia E.","family":"Kimonis","sequence":"additional","affiliation":[{"name":"Division of Genetics and Genomic Medicine, Department of Pediatrics University of California  Irvine California"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,7,16]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320350306"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.pmbts.2015.12.003"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.113.3.565"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmedgenet-2018-105301"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-33536-0"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009-1389"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2008.165"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/gim.0b013e31822bead0"},{"key":"e_1_2_8_10_1","volume-title":"The Stanford\u2010Binet intelligence scale, fourth edition: Examiner's handbook","author":"Delaney E. 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