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Genetic mutations have been implicated in the development of PCG, but little is known about nongenetic risk factors. This study investigates potential risk factors for PCG in the National Birth Defects Prevention Study (NBDPS), a large population\u2010based case\u2013control study of major birth defects in the United States. The analysis includes case infants with PCG (<jats:italic>N<\/jats:italic> =\u2009107) and control infants without birth defects (<jats:italic>N<\/jats:italic> = 10,084) enrolled in NBDPS from birth years 2000\u20132011. Pregnancy\/infant clinical characteristics, demographics, and parental health history were collected through maternal interview. Adjusted odds ratios (aORs) and 95% confidence intervals (CIs) were computed to examine associations with all PCG cases and isolated PCG cases without other major malformations. Associations with all the cases included term low birth weight (&lt;2,500\u2009g; aOR = 2.80, CI 1.59\u20134.94), non\u2010Hispanic black maternal race\/ethnicity (aOR = 2.42, CI 1.42\u20134.13), maternal history of seizure (aOR = 2.73, CI 1.25\u20135.97), maternal antihypertensive use (aOR = 3.60, CI 1.52\u20138.53), and maternal sexually transmitted infection (aOR = 2.75, CI 1.17\u20136.44). These factors were also associated with isolated PCG, as was maternal use of nonsteroidal anti\u2010inflammatory drugs (aOR = 2.70, CI 1.15\u20136.34). This study is among the first to examine a wide array of potential risk factors for PCG in a population\u2010based sample.<\/jats:p>","DOI":"10.1002\/ajmg.a.61296","type":"journal-article","created":{"date-parts":[[2019,7,17]],"date-time":"2019-07-17T05:57:51Z","timestamp":1563343071000},"page":"1846-1856","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Risk factors for primary congenital glaucoma in the National Birth Defects Prevention Study"],"prefix":"10.1002","volume":"179","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7894-0279","authenticated-orcid":false,"given":"Nina E.","family":"Forestieri","sequence":"first","affiliation":[{"name":"North Carolina Birth Defects Monitoring Program, State Center for Health Statistics  Raleigh North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tania A.","family":"Desrosiers","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Gillings School of Global Public Health, University of North Carolina at Chapel Hill  Chapel Hill North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon F.","family":"Freedman","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Pediatrics Duke University Medical Center  Durham North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur S.","family":"Aylsworth","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Genetics University of North Carolina at Chapel Hill  Chapel Hill North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin","family":"Voltzke","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Gillings School of Global Public Health, University of North Carolina at Chapel Hill  Chapel Hill North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew F.","family":"Olshan","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Gillings School of Global Public Health, University of North Carolina at Chapel Hill  Chapel Hill North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert E.","family":"Meyer","sequence":"additional","affiliation":[{"name":"North Carolina Birth Defects Monitoring Program, State Center for Health Statistics  Raleigh North Carolina"},{"name":"Department of Maternal and Child Health Gillings School of Global Public Health, University of North Carolina at Chapel Hill  Chapel Hill North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"The National Birth Defects Prevention Study","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,7,16]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"2911","article-title":"Screening of CYP1B1 and LTBP2 genes in Saudi families with primary congenital glaucoma: Genotype\u2010phenotype correlation","volume":"17","author":"Abu\u2010Amero K. 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