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To assess whether patients with 22q11.2DS are vulnerable to adverse effects of antipsychotic medication, we carried out a literature review. A systematic search strategy was performed using PubMed (Medline), Embase, PsychInfo, and Cochrane Database of Systematic Reviews. Publications describing adverse effects of antipsychotic medication in patients with 22q11.2DS were included in the review and assessed for their methodological quality. A total of 11 publications reporting on eight trials, cross\u2010sectional or cohort studies, and 30 case reports were included. The most commonly reported adverse effects can be classified into the following categories: movement disorders, weight gain, seizures, cardiac side effects, and cytopenias. Many of these symptoms are manifestations of 22q11.2DS, also in the absence of antipsychotic medication. Based on the reviewed literature, a causal relation between antipsychotic medication and the reported adverse effects could not be established in the majority of cases. Randomized clinical trials are needed to make firm conclusions regarding risk of adverse effects of antipsychotics in patients with 22q11.2DS.<\/jats:p>","DOI":"10.1002\/ajmg.a.61324","type":"journal-article","created":{"date-parts":[[2019,8,13]],"date-time":"2019-08-13T11:55:55Z","timestamp":1565697355000},"page":"2292-2306","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Adverse effects of antipsychotic medication in patients with 22q11.2 deletion syndrome: A systematic review"],"prefix":"10.1002","volume":"179","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1231-2733","authenticated-orcid":false,"given":"Janna","family":"de Boer","sequence":"first","affiliation":[{"name":"Department of Psychiatry University Medical Center Utrecht, Utrecht University &amp; University Medical Center Utrecht Brain Center  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik","family":"Boot","sequence":"additional","affiliation":[{"name":"'s Heeren Loo Zorggroep  Amersfoort The Netherlands"},{"name":"The Dalglish Family 22q Clinic, University Health Network  Toronto Ontario Canada"},{"name":"Department of Nuclear Medicine Amsterdam UMC  Amsterdam The Netherlands"},{"name":"Department of Psychiatry &amp; Neuropsychology Maastricht University  Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lissa","family":"van Gils","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University Medical Center Utrecht, Utrecht University &amp; University Medical Center Utrecht Brain Center  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Therese","family":"van Amelsvoort","sequence":"additional","affiliation":[{"name":"Department of Psychiatry &amp; Neuropsychology Maastricht University  Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janneke","family":"Zinkstok","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University Medical Center Utrecht, Utrecht University &amp; University Medical Center Utrecht Brain Center  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,8,13]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1089\/cap.2016.0044"},{"issue":"7","key":"e_1_2_8_3_1","first-page":"22","article-title":"Antipsychotic\u2010induced weight gain: A review of the literature","volume":"62","author":"Allison D. 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