{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:56:55Z","timestamp":1787165815242,"version":"build-2736575974"},"reference-count":15,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,12,12]],"date-time":"2019-12-12T00:00:00Z","timestamp":1576108800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J of Med Genetics Pt A"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Familial amniotic band sequence (ABS) is rare but has been reported in the offspring of mothers with connective tissue disorders. We present a family of two half\u2010siblings with ABS who share the same biological father. Following a serious vascular event a de novo pathogenic variant in\n                    <jats:italic>COL3A1<\/jats:italic>\n                    was detected in the father, confirming a diagnosis of vascular Ehlers\u2013Danlos syndrome (vEDS). The same variant was found in both his ABS\u2010affected children but not in his unaffected child. The amniotic membrane is derived from fetal tissue, type III collagen being a component. As the affected children are paternal half\u2010siblings, ABS was less likely due to maternal factors. Rather, the amniotic bands may have resulted from decreased type III collagen production as seen in people with vEDS, causing fragility of the amniotic membrane. Consequently, it is important to consider vEDS in patients with ABS.\n                  <\/jats:p>","DOI":"10.1002\/ajmg.a.61449","type":"journal-article","created":{"date-parts":[[2019,12,13]],"date-time":"2019-12-13T01:38:32Z","timestamp":1576201112000},"page":"553-556","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Amniotic band sequence in paternal half\u2010siblings with vascular Ehlers\u2013Danlos syndrome"],"prefix":"10.1002","volume":"182","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7047-041X","authenticated-orcid":false,"given":"Mary B.","family":"Callaghan","sequence":"first","affiliation":[{"name":"Clinical Genetics Royal Devon and Exeter NHS Foundation Trust  Exeter UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rob","family":"Hadden","sequence":"additional","affiliation":[{"name":"Department of Pathology Derriford Hospital  Plymouth UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jon S.","family":"King","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Derriford Hospital  Plymouth UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Lachlan","sequence":"additional","affiliation":[{"name":"Wessex Clinical Genetics Service Princess Anne Hospital  Southampton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fleur S.","family":"van Dijk","sequence":"additional","affiliation":[{"name":"Complex Ehlers\u2010Danlos Syndromes National Service London North West University Healthcare NHS Trust  Harrow Middlesex UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter D.","family":"Turnpenny","sequence":"additional","affiliation":[{"name":"Clinical Genetics Royal Devon and Exeter NHS Foundation Trust  Exeter UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,12,12]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2008.12.007"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCD.0b013e3283365a6a"},{"key":"e_1_2_9_4_1","volume-title":"GeneReviews\u00ae","author":"Byers P. 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